2026-10-14T05:49:24Z
https://api.figshare.com/v2/oai
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2026-09-16T17:22:23Z
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month_year_09_2026
<p>Effect of METC on gastric measurements.</p>
Hanan Ibrahim Alsharif (23672654)
Mohammad Khaled Abu-Sini (24998478)
Abdulrahman Ismael (24998481)
Naz Farhad Abdulqadir (24998484)
Gharieb S. El-Sayyad (12680796)
Ahmed A.J. Jabbar (22857275)
Sara Basil Abu Jalboush (24998487)
Rawan Fahad Mosallam Almehmadi (24998490)
Talal Salem Al-Qaisi (12258681)
Khalid M. Alqaisi (23672657)
Biochemistry
Space Science
Microbiology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Immunology
Biological Sciences not elsewhere classified
Science Policy
week toxicity study
induced gastric ulceration
either normal saline
95 %, 30
94 %, 179
92 %, respectively
64 %, respectively
59 %, 47
tragopogon coelesyriacus </
significant gastroprotective potential
induced gastric ulcer
increasing hsp 70
36 %; il
histopathological results showed
5 %, respectively
kg ),</ b
increasing il
50 %,
32 %,
vivo </
ulcer controls
gastroprotective potency
5 ml
5 groups
5 g
</ b
viable source
suppressed ethanol
superoxide dismutase
physiological alterations
oxidative stress
outcomes highlight
mucus secretion
mucous metaplasia
methanolic extracts
mainly associated
lowering bax
lesioned areas
gastrointestinal disorders
epithelial exfoliation
decreasing tnf
behavioral changes
attenuates ethanol
>: modulation
400 mg
<div><p><i>Tragopogon coelesyriacus</i> is a traditional herbal medicine used for gastrointestinal disorders, mediated by its phytoconstituents. This study explores acute toxicity and gastroprotective potency of methanolic extracts of <i>Tragopogon coelesyriacus</i> (METC) in rats. Rats were aligned in 5 groups and pretreated with either normal saline, lansoprazole, or METC (200 and 400 mg/kg) before 5 mL/kg ethanol-induced gastric ulceration. The two-week toxicity study for METC (2 and 5 g/kg) showed no physiological alterations, behavioral changes, or morbidity in rats. Pretreatment with METC (200 and 400 mg/kg) improved gastric defense factors (mucus secretion and total stomach acidity), limiting mucosal penetrations and the lesioned areas. The histopathological results showed that METC (200 and 400 mg/kg) suppressed ethanol-induced gastric tissue alterations, indicated by increased gastric protective percentages (51.02% and 65.67%), less submucosal edema, epithelial exfoliation, lower <b>mucous metaplasia, and necrotic areas.</b> METC <b>supplementation (200 and 400 mg/kg) restored the level of</b> superoxide dismutase and catalase, while reducing the MDA by 29.84% and 48.64%, respectively. This was parallel with the anti-inflammatory effects of METC (200 and <b>400 mg/kg),</b> decreasing TNF-α by 34.59%, 47.36%; IL-6 by 24.95%, 30.32%, and increasing IL-10 by 73.94%, 179.92%, respectively, relative to ulcer controls. Additionally, METC (200 and 400 mg/kg) remarkably modulated apoptotic proteins, lowering Bax by 31.10% and 45.50%, and increasing HSP 70 by 28.12 and 65.5%, respectively. The outcomes highlight the significant gastroprotective potential of <i>Tragopogon coelesyriacus</i>, which was mainly associated with its antioxidant, anti-inflammatory, and anti-apoptosis properties, making it a viable source for gastric ulcer management.</p></div>
2026-09-16T17:22:07Z
Dataset
Dataset
10.1371/journal.pone.0355381.t001
https://figshare.com/articles/dataset/_p_Effect_of_METC_on_gastric_measurements_p_/33865152
CC BY 4.0