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oai:figshare.com:article/33851692 2026-09-16T13:52:35Z portal_1197 item_type_3 month_year_09_2026

Data for Lithiation-Functionalisation of Triazoles Bearing Electron-Withdrawing N-Substituents: Challenges and Solutions Frances E. Bugden (24985741) Guy J. Clarkson (1301127) Mark D. Greenhalgh (1717120) Triazoles Electrons Migrated from ePrints The regioselective lithiation of 1,2,3-triazoles provides an opportunity to introduce additional functionality, however this simple functionalisation strategy using triazoles bearing electron-withdrawing N-substituents has not been investigated until now. Herein, we demonstrate that the lithiated triazole intermediates can readily decompose, even at −78 °C. In addition, lithiation-deuteration studies reveal lithiation can take place competitively on both the triazole and the electron-withdrawn aryl ring. Careful control of reaction conditions is therefore required to i) minimise decomposition pathways; and ii) facilitate regioselective functionalisation of the triazole.<br><br>All raw and processed data (NMR, IR, HRMS) that underpins the following publication. All folder names correspond to compound numbers in the manuscript. 2022-11-09T00:00:00Z Dataset Dataset 10.82444/warw.33851692.v1 https://figshare.com/articles/dataset/Data_for_Lithiation-Functionalisation_of_Triazoles_Bearing_Electron-Withdrawing_N-Substituents_Challenges_and_Solutions/33851692 CC BY 4.0