2026-10-13T09:51:26Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33850444 2026-09-16T13:31:08Z portal_1197 item_type_3 month_year_09_2026

Data for The first mitotic division of human embryos is highly error prone Cerys E. Currie (24897259) Emma Ford (23639174) Lucy Benham Whyte (24984574) Deborah M. Taylor (24798352) Bettina P. Mihalas (21278507) Muriel Erent (185011) Adele L. Marston (17659173) Geraldine M. Hartshorne (24731692) Andrew D. McAinsh (14305370) Mitosis Aneuploidy Human embryo Migrated from ePrints Aneuploidy in human embryos is surprisingly prevalent and increases drastically with maternal age, resulting in miscarriages, infertility and birth defects. Frequent errors during the meiotic divisions cause this aneuploidy, while age-independent errors during the first cleavage divisions of the embryo also contribute. However, the underlying mechanisms are poorly understood, largely because these events have never been visualised in living human embryos. Here, using cell-permeable DNA dyes, we film chromosome segregation during the first and second mitotic cleavage divisions in human embryos from women undergoing assisted reproduction following ovarian stimulation. We show that the first mitotic division takes several hours to complete and is highly variable. Timings of key mitotic events were, however, largely consistent with clinical videos of embryos that gave rise to live births. Multipolar divisions and lagging chromosomes during anaphase were frequent with no maternal age association. In contrast, the second mitosis was shorter and underwent mostly bipolar divisions with no detectable lagging chromosomes. We propose that the first mitotic division in humans is a unique and highly error-prone event, which contributes to fetal aneuploidies.<br><br>The dataset contains movies of human embryos consented to research progressing through the first two embryonic mitoses. The chromosomes have been visualised using SiR-DNA dye and imaged using a deltavision widefield microscope. The dataset consists only of time lapse imaging movies. Open access data is available at OMERO at Warwick: https://omero.warwick.ac.uk/ Details for how to access the dataset are available on the public data page: https://warwick.ac.uk/fac/sci/med/research/biomedical/facilities/camdu/publicdata/ 2026-09-16T13:31:08Z Dataset Dataset 10.82444/warw.33850444.v1 https://figshare.com/articles/dataset/Data_for_The_first_mitotic_division_of_human_embryos_is_highly_error_prone/33850444 CC BY 4.0