2026-10-14T03:53:58Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33845365 2026-09-16T11:59:13Z category_16 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Aluminium neurotoxicity beyond the brain: a mechanistic systematic review of autonomic and peripheral dysfunction.doc Trina Sengupta (24979447) Tripti Sharma (4587601) Prasunpriya Nayak (55186) Sovan Bagchi (24979450) Physiology aluminium autonomic nervous system baroreflex sensitivity blood-brain barrier central nervous system enteric nervous system heavy metals nervous system <p>Aluminium (Al) is a ubiquitous environmental neurotoxicant primarily recognized for its role in central nervous system (CNS) dysfunction. However, emerging evidence suggests that the autonomic (ANS) and peripheral (PNS) nervous systems may be susceptible to Al-induced damage earlier than the CNS, offering potential windows for early detection. This mechanistic systematic review synthesizes current human, animal, and mechanistic evidence to evaluate the multisystemic effects of Al beyond the CNS and to identify potential candidate markers of exposure. Following PRISMA guidelines, a comprehensive search was conducted across five databases (PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library). Sixteen primary studies that met strict inclusion criteria were analyzed. Given the heterogeneity of the data, a mechanistic synthesis was employed to map pathways and link them to clinical observations. Synthesis of the evidence reveals a consistent “Barrier-Stress Axis.” Mechanistically, Al targets tight junction proteins (e.g., occludin, claudin-5) in the blood-brain and blood-nerve barriers, leading to oxidative stress in the nucleus tractus solitarius and peripheral nerves. Clinically, this manifests as reduced heart rate variability (HRV) and impaired baroreflex sensitivity in both occupational human cohorts and experimental rat models. While peripheral nerve conduction changes are noted, human data remain limited by small sample sizes and confounding environmental factors. Preliminary evidence suggests that ANS and PNS dysregulation may precede overt cognitive decline in Al toxicity. HRV and baroreflex sensitivity are promising candidates for early-stage screening. However, these findings should currently be viewed as hypothesis-generating; longitudinal human studies are required to validate these markers and control for occupational co-exposures.</p> 2026-09-16T11:59:13Z Dataset Dataset 10.3389/fphys.2026.1891526.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Aluminium_neurotoxicity_beyond_the_brain_a_mechanistic_systematic_review_of_autonomic_and_peripheral_dysfunction_doc/33845365 CC BY 4.0