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oai:figshare.com:article/33830356 2026-09-16T07:23:18Z portal_1197 item_type_3 month_year_09_2026

Data for Covalent cell surface recruitment of chemotherapeutic polymers enhances selectivity and activity Ruben M. F. Tomás (24906688) Matthew I. Gibson (1273788) Drug resistance in cancer cells Oligosaccharides Cell membranes Peptide antibiotics Migrated from ePrints Synthetic macromolecular chemotherapeutics inspired by host defence peptides can disrupt cell membranes and are emerging as agents for the treatment of cancer and infections. However, their off-target effects remain a major unmet challenge. Here we introduce a covalent recruitment strategy, whereby metabolic oligosaccharide engineering is used to label targeted cells with azido glycans, to subsequently capture chemotherapeutic polymers by a bio-orthogonal click reaction. This results in up to 10-fold reduction in EC50 and widening of the therapeutic window. Cell death is induced by not only membrane leakage, but also by apoptosis due to the conjugated chemotherapeutic being internalised by glycan recycling. Covalent recruitment also lead to increased penetration and significant cell death in a 3-D tumour model in just 3 hours, whereas doxorubicin required 24 hours. This conceptual approach of ‘engineering cells to capture polymers’ rather than ‘engineering polymers to target cells’ will bring new opportunities in non-traditional macromolecular therapeutics.<br><br>Tabulated data underpinning the manuscript Data is organised according to each figure in the main paper and supporting information and the heading and legend of each figure can be used to understand the contents. All headings are explained in the individual tabs of the worksheet 2021-08-19T00:00:00Z Dataset Dataset 10.82444/warw.33830356.v1 https://figshare.com/articles/dataset/Data_for_Covalent_cell_surface_recruitment_of_chemotherapeutic_polymers_enhances_selectivity_and_activity/33830356 CC BY 4.0