2026-10-10T08:24:57Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33829255 2026-09-16T05:43:07Z category_15 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_A pH-responsive and self-healing CEC/PEG-(CHO)2 hydrogel for controlled neuropeptide S delivery and endogenous neural repair after spinal cord injury.docx Bai Xu (5773472) Mengdan Cheng (24961402) Yan Gao (93649) Yiqing Wu (298742) Ran Xu (316855) Wentao Shi (418559) Peng Zhao (128233) Xiaojie Lu (1317612) Neuroscience CEC/PEG-(CHO)2 scaffold endogenous neural stem/progenitor cells nerve regeneration neuropeptide S (NPS) spinal cord injury <p>A pH-responsive CEC/PEG-(CHO)₂ hydrogel scaffold was engineered for local delivery of neuropeptide S (NPS) to modulate the hostile microenvironment after spinal cord injury (SCI). The scaffold exhibited accelerated degradation under acidic conditions mimicking the injured site, enabling controlled release of NPS. Its porous microstructure (50−150 μm pore size) and compressive elastic modulus (0.081 MPa, slightly softer than that of a native spinal cord) provide a mechanical microenvironment conducive to neuronal survival and differentiation. In a T11 complete transection mouse model, the NPS-loaded scaffold significantly attenuated local inflammation (reduced MMP-9, TNF-α, CD68; increased IL-10), suppressed glial scar formation, recruited endogenous Nestin⁺ neural stem/progenitor cells (NSPCs), and promoted their differentiation into mature MAP2⁺ neurons with enhanced myelination (MBP⁺) and synaptic integration (SYP⁺/MAP2⁺). These effects were mediated through the NPS-NPSR axis and downstream Ca^{2 +}/cAMP signaling pathways. This study demonstrates that a rationally designed pH-responsive hydrogel can effectively remodel the SCI microenvironment and activate endogenous neural repair mechanisms, offering a promising strategy for SCI treatment.</p> 2026-09-16T05:43:07Z Dataset Dataset 10.3389/fnins.2026.1933351.s001 https://figshare.com/articles/dataset/Data_Sheet_1_A_pH-responsive_and_self-healing_CEC_PEG-_CHO_2_hydrogel_for_controlled_neuropeptide_S_delivery_and_endogenous_neural_repair_after_spinal_cord_injury_docx/33829255 CC BY 4.0