2026-10-14T17:53:28Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33827764 2026-09-16T04:32:47Z category_388 portal_316 item_type_2 month_year_09_2026

Video 1_Spinal granulocytic sarcoma with both extradural and intradural involvement: a case report.mp4 Jian Zhang (1682) Bao-Guo Han (24960514) Yan-Hao Ge (24960517) Ting-Chen Zhu (24960520) Ya-Feng Zhang (428307) Oncology and Carcinogenesis not elsewhere classified granulocytic sarcoma intradural laminectomy leukemia relapse nerve sheath tumors Introduction<p>Granulocytic sarcoma (GS) is a rare extramedullary accumulation of myeloid blasts. Cases of GS with isolated intradural presentation sparing the underlying bone are extremely rare.</p>Case description<p>A 75-year-old male patient with a remote history of acute myeloid leukemia (AML) in 30-year remission presented with progressive lumbar radiculopathy. Magnetic Resonance Imaging (MRI) revealed intradural lesions spanning L2–S1, mimicking nerve sheath tumors. The patient underwent emergency laminectomy and resection of a vascular, grayish-green L2 mass adherent to the cauda equina. Immunohistochemistry confirmed it was a GS (MPO+, CD43+, CD68+) with no evidence of bone marrow relapse. Following surgery and consolidation chemotherapy, the patient’s neurological status improved (ASIA C to D). However, he developed disseminated CNS relapse four months later and succumbed to disease progression 7 months postoperatively.</p>Conclusion<p>Isolated intradural GS constitutes a rare manifestation of extramedullary AML relapse and frequently masquerades radiologically as common benign nerve sheath tumors. While urgent surgical decompression facilitates significant neurological recovery, long-term survival is strictly dictated by the efficacy of systemic disease control. Therefore, adopting a multidisciplinary strategy integrating intraoperative frozen-section analysis, rigorous immunohistochemical profiling, and early adjuvant chemotherapy is paramount for avoiding diagnostic delays and optimizing patient outcomes.</p> 2026-09-16T04:32:47Z Dataset Media 10.3389/fonc.2026.1832811.s001 https://figshare.com/articles/media/Video_1_Spinal_granulocytic_sarcoma_with_both_extradural_and_intradural_involvement_a_case_report_mp4/33827764 CC BY 4.0