2026-10-14T07:47:22Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33827530 2026-09-16T04:29:42Z category_696 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Plasma membrane damage by environmental materials enhances cell-cell fusion and impairs defense functions of macrophages.pdf Dandan Wu (163131) Xing Zhang (11943) Ruoning Wang (4135336) Amanda Livingston (24960364) Xinyi Lu (547845) Eliane El Hayek (14701820) Xiang Xue (840513) Aaron Neumann (24960367) Matthew Campen (3567395) Meilian Liu (553341) Xuexian O. Yang (22991192) Genetic Immunology environmental material host defense macrophage membrane damage phagocytosis Introduction<p>Many environmental materials can activate macrophages and trigger inflammatory responses. However, whether and how these exposures alter macrophage function in host defense remains elusive.</p>Methods<p>Bone marrow-derived macrophages were treated with various environmental materials, including laundry detergent, and their membrane damage was measured by Annexin V staining. Alterations in macrophage function were assessed by cell-cell fusion, in vitro phagocytosis, and in vivo clearance of Candida albicans.</p>Results and Discussion<p>Many environmental hazards damage the plasma membranes of macrophages. This damage decreases macrophage phagocytosis but elevates cell-cell fusion. In vivo, airway exposure to laundry detergent impairs the recruitment of macrophages and other myeloid cells to the lung and dramatically dampens protective TH1 and TH17 cell responses, thereby increasing susceptibility to Candida infection in mice. Overall, our data indicate that exposure to environmental materials compromises macrophage membrane integrity and impairs host defense. These findings may aid in developing effective preventive and therapeutic strategies.</p> 2026-09-16T04:29:42Z Dataset Dataset 10.3389/fimmu.2026.1898611.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Plasma_membrane_damage_by_environmental_materials_enhances_cell-cell_fusion_and_impairs_defense_functions_of_macrophages_pdf/33827530 CC BY 4.0