2026-10-13T01:55:01Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33827103 2026-09-16T04:08:53Z category_7 category_16 category_24 category_873 category_45 category_61 category_62 category_69 portal_63 item_type_3 month_year_09_2026

A Digitally Controlled Flow–Batch Platform for Reproducible Radical Copolymerization with Reduced Composition Drift Araki Wakiuchi (15854449) Shigehito Asano (2418103) Shogo Takasuka (20186022) Yosuke Harashima (20186028) Tomoaki Takayama (1597057) Tsuyoshi Ando (2373463) Miho Hatanaka (1364469) Yu-ya Ohnishi (1722988) Takamitsu Matsubara (15854452) Tomoyuki Miyao (1403347) Tetsunori Sugawara (15854455) Hiroharu Ajiro (1522708) Mikiya Fujii (1475200) Medicine Physiology Evolutionary Biology Chemical Sciences not elsewhere classified Sociology Developmental Biology Marine Biology Inorganic Chemistry widely used industrially tested operating window separating thermal preconditioning rapid thermal preconditioning local flow conditions heated tubular reactor alter polymer properties reducing composition drift four batch reactors reproducible radical copolymerization radical copolymerization batch reactors reproducible small composition control yielding 1 weight fraction shifted initiator scale transfer point updates platform provides monomer data low conversion heat transfer empirically calibrated dry copolymer decay contributions 97 kg 8 h Free-radical copolymerization is widely used industrially, but scale transfer can alter polymer properties through changes in mixing and heat transfer. We developed a digitally controlled flow–batch platform integrating a micromixer, heated tubular reactor, and batch reactors. The flow stage provided reproducible mixing and rapid thermal preconditioning at low conversion, whereas the batch stage completed polymerization at high conversion and enabled programmed monomer dosing. Heating the shared upstream stage suppressed early formation of a high-molecular-weight fraction. A feed-rate function whose time dependence reflects superposed, time-shifted initiator-decay contributions was empirically calibrated from residual-monomer data and implemented through 1 min Pump C set-point updates, reducing composition drift. Timed valve switching enabled sequential use of four batch reactors under the same local flow conditions, yielding 1.97 kg of dry copolymer in 8 h. By separating thermal preconditioning from composition control, the platform provides a reproducible small-lot production strategy within the tested operating window. 2026-09-16T00:00:00Z Dataset Dataset 10.1021/acs.iecr.6c02783.s002 https://figshare.com/articles/dataset/A_Digitally_Controlled_Flow_Batch_Platform_for_Reproducible_Radical_Copolymerization_with_Reduced_Composition_Drift/33827103 CC BY-NC 4.0