2026-10-14T20:18:44Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33825676 2026-09-29T23:53:43Z category_25177 portal_12 item_type_5 month_year_09_2026

Lora Yuge Liu: Development of Targeted Therapy for the Treatment of Glioblastoma Yuge Liu (16820304) Biologically active molecules Medicinal Chemistry Drug Delivery NIR Imaging Agent Brain Cancer <p dir="ltr">Glioblastoma is one of the most aggressive primary brain cancers and remains difficult to treatbecause of its invasive nature, limited drug delivery across the blood-brain barrier (BBB), and hightumour heterogeneity 1 . Current treatments can slow disease progression but are rarely curative,highlighting the need for new approaches that improve the delivery of therapeutic agents to tumourtissue.This project investigates heptamethine cyanine dyes (HMCDs) as tumour-targeting carriers for thedevelopment of drug-dye conjugates. These near-infrared fluorescent molecules are of interestbecause of their reported preferential accumulation in several brain tumour types and their potential tocombine tumour targeting with optical imaging 2 . A modular synthetic strategy has been developed toattach different therapeutic molecules to a cyanine dye scaffold, allowing the preparation ofconjugates with different structures and drug-loading patterns.The resulting compounds are characterised using analytical and spectroscopic techniques andevaluated in glioblastoma cell models to investigate their cellular uptake and biological activity.Computational approaches are also being used to support the design and interpretation of selectedconjugates. Together, this work aims to establish a flexible chemical platform for developing tumour-targeted therapeutic agents and to explore its potential application in glioblastoma treatment.</p> 2026-09-29T23:53:43Z Image Poster 10.17608/k6.auckland.33825676.v2 https://figshare.com/articles/poster/Development_of_Targeted_Therapy_for_the_Treatment_of_Glioblastoma/33825676 CC BY 4.0