2026-10-14T04:56:34Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/33816310
2026-09-15T18:15:48Z
category_7
category_8
category_39
category_46
category_64
category_132
category_134
category_135
portal_5
item_type_3
month_year_09_2026
<p>Participants’ demographic characteristics.</p>
Clara Clavery Lubinza (24951064)
Alina Johanna Anton (24951067)
Simone Lueert (8929184)
Eugene Adade (24951070)
Idrissa Shomari Chuma (24951073)
Augustina Angelina Sylverken (9756702)
David Šmajs (48851)
Sayoki Godfrey Mrinde Mfinanga (24951076)
Christian Roos (141269)
Sascha Knauf (111363)
Medicine
Microbiology
Ecology
Immunology
Cancer
Infectious Diseases
Virology
Computational Biology
reported nonhuman primate
rapid plasma reagin
potential zoonotic nature
particle agglutination assay
common differential diagnosis
56 primary schools
ulcer swab samples
study also aimed
haemophilus ducreyi </
support tanzania ’
7 ± 2
3 ± 2
3 %, 95
treponema pallidum </
antibodies using treponemal
human yaws infection
pallidum </
study areas
human yaws
treponemal antibodies
serum samples
tpe </
pertenue </
hd </
yaws bacterium
still circulating
skin ulcers
skin lesions
sectional design
quantitative pcr
likely interrupted
genotype class
first data
february 2019
continued surveillance
certification free
august 2018
anti -<
9 %)
<div>
<p>Background</p><p>To support Tanzania’s quest for certification free of human yaws, we tested children with skin ulcers for yaws infection living near areas of reported nonhuman primate (NHP) infection with <i>Treponema pallidum</i> subsp. <i>pertenue</i> (<i>TPE</i>). The study also aimed to test children for infection with <i>Haemophilus ducreyi</i> (<i>HD</i>), the most common differential diagnosis for yaws.</p>
<p>Methodology/principal findings</p><p>A cross-sectional design was used to study primary school children with skin ulcers living near wildlife areas with <i>TPE</i> infected NHPs. Serum and ulcer swab samples were collected from the children. Serum samples were tested for anti-<i>T</i>. <i>pallidum</i> antibodies using treponemal (Particle Agglutination Assay) and non-treponemal (Rapid Plasma Reagin) tests. Ulcer swab samples were tested by quantitative PCR (qPCR) for the presence of <i>TPE</i> and <i>HD</i> bacteria. 612 children were recruited from 56 primary schools between August 2018 and February 2019. The mean age ± SD was 10.3 ± 2.3 and 10.7 ± 2.4 years for girls and boys, respectively. While none of the tested children had treponemal or non-treponemal antibodies, 21 (5.3%, 95% CI = 3.5% - 7.9%) were tested positive for <i>HD</i> by qPCR. Only strains that fall into the <i>HD</i> genotype class I were detected.</p>
<p>Conclusions/significance</p><p>We show that human yaws infection is likely interrupted in the study areas, although the yaws bacterium is still circulating in NHPs. Due to the potential zoonotic nature of NHP-infecting strains, continued surveillance is needed for yaws and <i>HD</i> infection. Here, we provide the first data on <i>HD</i> associated (non-genital) skin lesions in Tanzanian children.</p></div>
2026-09-15T18:10:47Z
Dataset
Dataset
10.1371/journal.pntd.0014567.t001
https://figshare.com/articles/dataset/_p_Participants_demographic_characteristics_p_/33816310
CC BY 4.0