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          <dc:title>&lt;p&gt;Genes within the 16,493 bp deleted region of SgGmmC1* according to the SgGmmB4 reference [16]. Gene names and products were annotated using PROKKA; conserved orthologous groups were assigned using the STRING database; gene ontology and conserved regions were assigned using the Interpro database. Key: CDS – coding DNA sequence; pseudo – pseudogene; COG – clustered orthologous group; GO – gene ontology. Yellow – pseudogenes; blue – CDS.&lt;/p&gt;</dc:title>
          <dc:creator>Poppy Pescod (11203648)</dc:creator>
          <dc:creator>Lee R. Haines (10035677)</dc:creator>
          <dc:creator>Alistair C. Darby (11473533)</dc:creator>
          <dc:creator>Ian Goodhead (30391)</dc:creator>
          <dc:subject>Microbiology</dc:subject>
          <dc:subject>Cell Biology</dc:subject>
          <dc:subject>Genetics</dc:subject>
          <dc:subject>Evolutionary Biology</dc:subject>
          <dc:subject>Environmental Sciences not elsewhere classified</dc:subject>
          <dc:subject>Ecology</dc:subject>
          <dc:subject>Biological Sciences not elsewhere classified</dc:subject>
          <dc:subject>Marine Biology</dc:subject>
          <dc:subject>Infectious Diseases</dc:subject>
          <dc:subject>supports previous hypotheses</dc:subject>
          <dc:subject>scale chromosomal mutations</dc:subject>
          <dc:subject>paratransgenic approaches using</dc:subject>
          <dc:subject>novel ecological niches</dc:subject>
          <dc:subject>illumina technologies produced</dc:subject>
          <dc:subject>identified multiple small</dc:subject>
          <dc:subject>hemolysin precursor (&lt;</dc:subject>
          <dc:subject>extensive pseudogene content</dc:subject>
          <dc:subject>div &gt;&lt; p</dc:subject>
          <dc:subject>complementary metabolic pathways</dc:subject>
          <dc:subject>comparative genomic analysis</dc:subject>
          <dc:subject>comparative analysis revealed</dc:subject>
          <dc:subject>49 %, vs</dc:subject>
          <dc:subject>containing 31 genes</dc:subject>
          <dc:subject>undergo genome degradation</dc:subject>
          <dc:subject>facultative bacterial endosymbiont</dc:subject>
          <dc:subject>wigglesworthia glossinidia &lt;/</dc:subject>
          <dc:subject>bacterial symbionts adapting</dc:subject>
          <dc:subject>recent evolutionary transition</dc:subject>
          <dc:subject>facultative tsetse symbiont</dc:subject>
          <dc:subject>sodalis glossinidius &lt;/</dc:subject>
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          <dc:subject>facultative symbionts</dc:subject>
          <dc:subject>bacterial symbionts</dc:subject>
          <dc:subject>evolutionary transition</dc:subject>
          <dc:subject>glossinidius &lt;/</dc:subject>
          <dc:subject>tsetse flies</dc:subject>
          <dc:subject>primary symbiont</dc:subject>
          <dc:subject>transition experimentally</dc:subject>
          <dc:subject>large genome</dc:subject>
          <dc:subject>genome evolution</dc:subject>
          <dc:subject>evolutionary trajectory</dc:subject>
          <dc:subject>vitro &lt;/</dc:subject>
          <dc:subject>thim &lt;/</dc:subject>
          <dc:subject>shla &lt;/</dc:subject>
          <dc:subject>thiamine biosynthesis</dc:subject>
          <dc:subject>ten years</dc:subject>
          <dc:subject>strains isolated</dc:subject>
          <dc:subject>significant deletion</dc:subject>
          <dc:subject>sggmmc1 *)</dc:subject>
          <dc:subject>sggmmb4 ).</dc:subject>
          <dc:subject>serial passaging</dc:subject>
          <dc:subject>selective pressures</dc:subject>
          <dc:description>&lt;p&gt;Genes within the 16,493 bp deleted region of SgGmmC1* according to the SgGmmB4 reference [&lt;a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0014725#pntd.0014725.ref016" target="_blank"&gt;16&lt;/a&gt;]. Gene names and products were annotated using PROKKA; conserved orthologous groups were assigned using the STRING database; gene ontology and conserved regions were assigned using the Interpro database. Key: CDS – coding DNA sequence; pseudo – pseudogene; COG – clustered orthologous group; GO – gene ontology. Yellow – pseudogenes; blue – CDS.&lt;/p&gt;</dc:description>
          <dc:date>2026-09-15T18:04:56Z</dc:date>
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          <dc:identifier>10.1371/journal.pntd.0014725.t001</dc:identifier>
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