2026-10-14T12:54:31Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33812065 2026-09-15T17:41:54Z category_1 category_4 category_7 category_13 category_14 category_19 category_21 category_502 category_734 category_931 category_64 category_122 portal_5 item_type_3 month_year_09_2026

<p>Supplementary data supporting the protein-protein interaction network, functional enrichment, drug-target, and structural analyses.</p> Thomas E. Diaz (18400530) Joseph A. Kerrigan Jr (24948778) Dawn E. Bowles (12068354) Yared H. Kidane (16814494) Biophysics Biochemistry Medicine Genetics Molecular Biology Pharmacology Biotechnology Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer Mental Health leveraging bioinformatics techniques leveraging bioinformatics approaches generate pharmacological hypotheses future computational characterization established pharmacological countermeasures duration spaceflight missions dock2 molecular docking accelerate pharmaceutical research predicted using drugst explored using cb generating structural assessments functional enrichment analyses experimentally supported interactions potential drug candidates identify candidate drugs space radiation countermeasures drug repositioning offers space radiation drug repositioning constructed using generating framework analyses demonstrate space medicine macromolecule interactions selected drug xlink "> systematic approach strategy introduces significant threat seed nodes protein interactions promising strategy markov clustering ion gcrs health effects gcrs ), gcr exposure experimental investigation <p>An excel workbook containing seven worksheets. S1 contains the differentially expressed proteins; S2 contains the protein-protein interaction network nodes, edges, and experimentally determined interactions; S3 contains the MCL cluster proteins, network topology, and predicted drug interactions; S4 contains the functional enrichment results; S5 contains the candidate drug characteristics and predicted protein interactions within MCL cluster 2; S6 contains the molecular docking and molecular dynamics simulations results from MCL cluster 2; S7 contains the drug-target interactions associated with MCL cluster 5.</p> <p>(XLSX)</p> 2026-09-15T17:41:46Z Dataset Dataset 10.1371/journal.pone.0357889.s005 https://figshare.com/articles/dataset/_p_Supplementary_data_supporting_the_protein-protein_interaction_network_functional_enrichment_drug-target_and_structural_analyses_p_/33812065 CC BY 4.0