2026-10-12T11:46:25Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/33811687
2026-09-15T17:39:43Z
category_7
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item_type_3
month_year_09_2026
<p>Quality assessment of selected studies.</p>
Desalegn Dawit Assele (11302533)
Yitayew Ewnetu Mohammed (20995640)
Abera Gezume Ganta (18155892)
Tadele Dana Darebo (3177465)
Sileshi Demelash Sasie (23180443)
Medicine
Biotechnology
Mathematical Sciences not elsewhere classified
Science Policy
Infectious Diseases
Virology
nos ), adapted
improve virological success
critical modifiable factor
viral suppression outcomes
viral load suppression
84 – 8
8 %– 83
observed across studies
antiretroviral therapy adherence
5 %– 81
2 </ sup
analysis </ p
good art adherence
estimate pooled prevalence
virologic suppression
pooled prevalence
good adherence
8 %).
observational studies
39 studies
final analysis
analysis aimed
art adherence
systematic reviews
systematic review
strongly associated
significantly associated
review protocol
relatively high
prisma checklist
plhiv ).
odds ratio
key determinant
highlighting adherence
google scholar
global targets
cochran ’
assessed using
19 ).
<div>
<p>Background</p><p>Antiretroviral therapy (ART) adherence is a key determinant of viral load suppression among people living with HIV (PLHIV). In Ethiopia, evidence on the magnitude of ART adherence and its effect on virological outcomes remains fragmented. This systematic review and meta-analysis aimed to estimate the pooled prevalence of ART adherence and viral load suppression, and to measure the association between adherence and viral suppression among PLHIV in Ethiopia.</p>
<p>Methods</p><p>This systematic review and meta-analysis used the PRISMA checklist for systematic reviews and meta-analyses. The review protocol has been registered onPROSPERO:(CRD420251125899). PubMed, ScienceDirect, Scopus, Epistemonikos, and Google Scholar were searched. The quality of included articles has been evaluated with a Newcastle–Ottawa Scale (NOS), adapted for observational studies. A random-effects model using restricted maximum likelihood (REML) with Knapp–Hartung adjustment was used to estimate pooled prevalence and odds ratio. Heterogeneity was assessed using I<sup>2</sup>, τ<sup>2</sup>, and Cochran’s Q test.</p>
<p>Results</p><p>A total of 39 studies were included in the final analysis. The pooled prevalence of good ART adherence was 79.4% (95% CI: 74.8%–83.4%), while the pooled viral load suppression rate was 77.5% (95% CI: 72.5%–81.8%). The pooled odds ratio showed that good ART adherence was strongly associated with viral load suppression (OR = 6.30, 95% CI: 4.84–8.19). Substantial heterogeneity was observed across studies for both adherence and viral suppression outcomes (I<sup>2</sup> > 90%).</p>
<p>Conclusions</p><p>ART adherence and viral load suppression among PLHIV in Ethiopia are relatively high but remain below global targets. Good adherence was significantly associated with virologic suppression, highlighting adherence as a critical modifiable factor for achieving optimal treatment outcomes. Strengthening adherence support interventions is essential to improve virological success and advance progress toward HIV epidemic control.</p></div>
2026-09-15T17:39:37Z
Dataset
Dataset
10.1371/journal.pone.0358352.s003
https://figshare.com/articles/dataset/_p_Quality_assessment_of_selected_studies_p_/33811687
CC BY 4.0