2026-10-13T23:25:27Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33810392 2026-09-15T17:31:41Z category_13 category_14 category_21 category_61 category_62 category_64 category_106 category_128 category_132 category_134 portal_5 item_type_3 month_year_09_2026

<p>Raw data used in Tables 1–4 and Fig 1.</p> Khomsan Yooyen (24948158) Seubsiri Bunditpirom (24948161) Supan Fucharoen (632578) Attawut Chaibunruang (15295468) Hataichanok Srivorakun (632574) Supawadee Yamsri (15295465) Genetics Molecular Biology Biotechnology Developmental Biology Marine Biology Cancer Science Policy Hematology Infectious Diseases Virology hb e co genetic hemoglobin disorders chronic kidney disease occurrence among patients adjusted odds ratios anemia included two 3 &# 8211 identify factors associated anemia among patients t2dm ), particularly xlink "> anemia xlink "> factors associated 001 ), t2dm patients significantly associated well characterized study aimed sociodemographic characteristics sectional study renal function relative contribution related hemoglobinopathies related genotypes promoting hospitals northeastern thailand iron status iron deficiency independent predictors hematologic indices findings highlight defined according confidence intervals common complication based cohort <div> <p>Introduction</p><p>Anemia is a common complication in individuals with type 2 diabetes mellitus (T2DM), particularly in regions where thalassemia and iron deficiency are prevalent. However, the relative contribution of genetic hemoglobin disorders in this context has not been well characterized. This study aimed to determine the prevalence of anemia and to identify factors associated with its occurrence among patients with T2DM in northeastern Thailand.</p> <p>Methods</p><p>A cross-sectional study was conducted among 210 patients with T2DM attending two community health-promoting hospitals in northeastern Thailand. Data on sociodemographic characteristics, hematologic indices, renal function, iron status, and thalassemia genotypes were collected. Anemia was defined according to World Health Organization criteria. Factors associated with anemia were evaluated using multivariable logistic regression analysis, and adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were reported.</p> <p>Results</p><p>The prevalence of anemia was 54.3%. Thalassemia and related hemoglobinopathies were present in 60.5% of participants, and iron deficiency in 39.5%. Independent predictors of anemia included two or more α-globin gene defects or Hb E co-inherited with α-thalassemia (adjusted OR: 37.8; p = 0.002), Hb E trait (OR: 3.6; p = 0.006), iron deficiency (OR: 3.7; p < 0.001), and chronic kidney disease stages 2 (OR: 3.5; p = 0.002) and 3–4 (OR: 15.7; p < 0.001).</p> <p>Conclusion</p><p>Anemia was highly prevalent among patients with T2DM in this community-based cohort from northeastern Thailand. Thalassemia-related genotypes, iron deficiency, and chronic kidney disease were significantly associated with anemia. These findings highlight the importance of considering inherited hemoglobin disorders when evaluating anemia in T2DM patients in hemoglobinopathy-endemic regions.</p></div> 2026-09-15T17:31:38Z Dataset Dataset 10.1371/journal.pone.0358120.s001 https://figshare.com/articles/dataset/_p_Raw_data_used_in_Tables_1_4_and_Fig_1_p_/33810392 CC BY 4.0