2026-10-14T20:03:13Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33804343 2026-09-15T15:54:18Z portal_1197 item_type_3 month_year_09_2026

Data for Combinatorial biomaterials discovery strategy to identify new macromolecular cryoprotectants Christopher D. Stubbs (24877378) Kathryn Murray (1332630) Toru Ishibe (7178540) Robert T. Mathers (1513891) Matthew I. Gibson (1273788) Cryochemistry Combinatorial chemistry Polyampholytes Migrated from ePrints Cryoprotective agents (CPAs) are typically solvents or small molecules, but there is a need for innovative CPAs to reduce toxicity and increase cell yield, for the banking and transport of cells. Here we use a photochemical high-throughput discovery platform to identify macromolecular cryoprotectants, as rational design approaches are currently limited by the lack of structure–property relationships. Using liquid handling systems, 120 unique polyampholytes were synthesized using photopolymerization with RAFT agents. Cryopreservation screening identified “hit” polymers and nonlinear trends between composition and function, highlighting the requirement for screening, with polymer aggregation being a key factor. The most active polymers reduced the volume of dimethyl sulfoxide (DMSO) required to cryopreserve a nucleated cell line, demonstrating the potential of this approach to identify materials for cell storage and transport.<br><br>Data record consists of a zip archive containing 7 subfolders and an index file for the data. Subfolders are organised and named according to the corresponding experiment in the related publication. All data files are in .xlsx format. Further information on the data can be found in the excel files containing the data themselves. 2020-05-05T00:00:00Z Dataset Dataset 10.82444/warw.33804343.v1 https://figshare.com/articles/dataset/Data_for_Combinatorial_biomaterials_discovery_strategy_to_identify_new_macromolecular_cryoprotectants/33804343 CC BY 4.0