2026-10-07T14:21:29Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33785824 2026-09-15T11:18:13Z category_24676 category_24685 item_type_3 month_year_09_2026

Rationally modified-CaCO₃ carriers for prolonged drug release and radionuclide retention in combination chemo-radionuclide therapy Darya Akhmetova (24926425) Alexander Timin (19691560) Nanomedicine Medical biotechnology not elsewhere classified calcium carbonate drug delivery systems prolonged release retention radionuclide therapy chemotherapy combined therapy <p dir="ltr">Here, we designed optimal conditions for high drug loading efficiency of 2AT and ²²³Ra with mutually improving therapeutic mechanisms of chemotherapy and α-radionuclide therapy. Importantly, the incorporation of 2AT and radiolabeling with ²²³Ra resulted in a slower dissolution of the CaCO₃ microparticles compared with the unloaded carrier. The resulting changes in carrier dissolution contribute to prolonged retention of the therapeutic components and provide sustained local exposure following intratumoral administration. The developed microparticles were comprehensively characterized, and their stability and release behavior were evaluated under different pH conditions. Their interaction with B16-F10 cells was investigated <i>in vitro</i>, while biodistribution, antitumor efficacy, and biosafety were evaluated in a murine solid tumor model. This study demonstrates the potential of controlling the physicochemical behavior of a CaCO₃ carrier through incorporation of chemically distinct therapeutic components to achieve prolonged local co-delivery of a chemotherapeutic agent and ²²³Ra.</p> 2026-09-15T11:18:13Z Dataset Dataset 10.6084/m9.figshare.33785824.v1 https://figshare.com/articles/dataset/Rationally_modified-CaCO_sub_3_sub_carriers_for_prolonged_drug_release_and_radionuclide_retention_in_combination_chemo-radionuclide_therapy/33785824 CC BY 4.0