2026-10-12T12:34:00Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33783562 2026-09-15T09:53:02Z category_1 category_4 category_7 category_8 category_19 category_21 category_873 category_734 category_64 portal_87 item_type_3 month_year_09_2026

Exploring the antidiabetic potential of DHA-salicylaldehyde-chalcone endowed 1,2,3-triazole hybrids: synthesis, α-glucosidase inhibition and molecular modeling studies Anshul Grover (24924469) Vivek Asati (11081343) Jayant Sindhu (634210) Kashmiri Lal (2442955) Biophysics Biochemistry Medicine Microbiology Pharmacology Biotechnology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Cancer α-glucosidase inhibition dehydroacetic acid salicylaldehyde triazoles molecular hybridization The present research work aims to synthesize and explore the in vitro α-glucosidase inhibition potentials of DHA-salicylaldehyde-chalcone endowed 1,2,3-triazoles to counter diabetes mellitus. A series of DHA-salicylaldehyde-chalcone endowed 1,2,3-triazole hybrids (4a-4l) was synthesized and characterized using various spectral techniques viz FTIR, NMR, and HRMS. The hybrids were further assayed for in vitro α-glucosidase inhibition. The findings were further justified by in silico studies. The findings of in vitro study suggested triazole hybrid 4k as the most potent α-glucosidase inhibitor (IC50 = 1.35 µM) compared to acarbose (IC50 = 13.5 µM). Molecular docking (MD) investigations of ligand-protein complex revealed favorable binding interactions. The hybrid 4k exhibited maximum inhibition of α-glucosidase enzyme with favorable binding interactions, suggesting this framework is a potential lead motif for future antidiabetic drug discovery. 2026-09-15T09:53:02Z Dataset Dataset 10.6084/m9.figshare.33783562.v1 https://figshare.com/articles/dataset/Exploring_the_antidiabetic_potential_of_DHA-salicylaldehyde-chalcone_endowed_1_2_3-triazole_hybrids_synthesis_-glucosidase_inhibition_and_molecular_modeling_studies/33783562 CC BY 4.0