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oai:figshare.com:article/33774247 2026-09-15T07:10:47Z portal_1197 item_type_3 month_year_09_2026

Data for Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans Ruben M. F. Tomás (24906688) Benjamin T. Martyn (24898882) Trisha L. Bailey (5843498) Matthew I. Gibson (1273788) Cell membranes Polymers Cellular therapy Migrated from ePrints Re-engineering mammalian cell surfaces enables modulation of their phenotype, function, and interactions with external markers and may find application in cell-based therapies. Here we use metabolic glycan labeling to install azido groups onto the cell surface, which can act as anchor points to enable rapid, simple, and robust “click” functionalization by the addition of a polymer bearing orthogonally reactive functionality. Using this strategy, new cell surface functionality was introduced by using telechelic polymers with fluorescence or biotin termini, demonstrating that recruitment of biomacromolecules is possible. This approach may enable the attachment of payloads and modulation of cell function and fate, as well as providing a tool to interface synthetic polymers with biological systems.<br><br>Data. File Excel spreadsheet containing raw data for all figures. Tabs in spreadsheet indicate the type of data, along with headings 2018-10-10T00:00:00Z Dataset Dataset 10.1021/acsmacrolett.8b00675 https://figshare.com/articles/dataset/Data_for_Engineering_cell_surfaces_by_covalent_grafting_of_synthetic_polymers_to_metabolically-labeled_glycans/33774247 CC BY 3.0