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oai:figshare.com:article/33771808 2026-09-15T05:36:07Z category_15 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Statin use and all-cause mortality in critically ill ischemic stroke patients: a time-dependent Cox analysis with external validation highlighting enhanced survival benefits in dementia subgroups.docx Danyu Li (20851958) Ruixin Liu (181600) Hui Xu (9203) Hongjie Tong (24912616) Kun Chen (131048) Jiali Yao (7303328) Neuroscience critical illness dementia ischemic stroke mortality statin Introduction<p>Ischemic stroke is a leading cause of mortality and disability, but the effect of statins on survival in critically ill patients, especially those with dementia, remains unclear.</p>Methods<p>This retrospective cohort study analyzed 1,964 patients from MIMIC-IV and validated findings in 4,255 external cases. Time-dependent Cox, IPTW, and PSM were applied.</p>Results<p>Statin use was significantly associated with reduced mortality at 30, 90, 180 days, and 1 year, though the effect attenuated over time. A significant statin-dementia interaction was observed, with greater benefit in dementia patients (adjusted HR = 0.548; NNT = 7 vs. 13). The strongest protection occurred immediately post-admission (74.1% risk reduction) and waned by 1 year. Results were robust in sensitivity and external validation.</p>Discussion<p>In conclusion, statin therapy improves short-to-medium-term survival in critically ill ischemic stroke patients, with potential additional benefits observed in those with dementia. These findings support early statin use and suggest dementia as a potential effect modifier, though prospective validation with standardized cognitive assessments is needed.</p> 2026-09-15T05:36:07Z Dataset Dataset 10.3389/fnagi.2026.1866416.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Statin_use_and_all-cause_mortality_in_critically_ill_ischemic_stroke_patients_a_time-dependent_Cox_analysis_with_external_validation_highlighting_enhanced_survival_benefits_in_dementia_subgroups_docx/33771808 CC BY 4.0