2026-10-08T09:03:35Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33771292 2026-09-15T04:55:05Z category_24178 category_24136 item_type_3 month_year_09_2026

<b>Comprehensive Characterization and Validation of a Severe Sepsis Rat Model Induced by Cecal Ligation and Puncture</b> Shuqi Ma (24912163) Lian Han (24912165) Min Tian (24912167) Tong Yang (24870412) Biochemistry and cell biology not elsewhere classified Analytical biochemistry Sepsis Cecal Ligation and Puncture Rat Model Hydrocortisone Inflammation <p dir="ltr">Severe sepsis requires reliable experimental models. We established and characterized a standardized rat severe sepsis model using cecal ligation and puncture (CLP). The model produced high mortality, physiological disturbances, inflammation, oxidative stress, hematological changes, and liver injury, while hydrocortisone improved outcomes. This model provides a reproducible platform for sepsis research and therapeutic evaluation.</p><p><br></p> 2026-09-15T04:55:05Z Dataset Dataset 10.6084/m9.figshare.33771292.v1 https://figshare.com/articles/dataset/_b_Comprehensive_Characterization_and_Validation_of_a_Severe_Sepsis_Rat_Model_Induced_by_Cecal_Ligation_and_Puncture_b_/33771292 CC BY 4.0 Open Access after 2026-11-04