2026-10-14T09:25:19Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33770827 2026-09-15T04:27:53Z category_696 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Association of serum magnesium levels with the risk of spontaneous bacterial peritonitis and sepsis in hospitalized patients with cirrhosis: a retrospective cohort study.docx Xiang-Jie Duan (22334722) Yang Cai (455523) Qing Su (251329) Qin Zhou (239082) Man Li (81239) Jin-Lian Chen (24912013) Chang-Yun Zhang (24912016) Duo-Meng Yang (24912019) Hai-Yan Yin (1626112) Wan-Jie Gu (404634) Genetic Immunology cirrhosis hypomagnesemia sepsis serum magnesium spontaneous bacterial peritonitis Background<p>Hypomagnesemia is common in patients with cirrhosis. This study aimed to examine the association between serum magnesium levels and the risks of hospital-acquired spontaneous bacterial peritonitis (HA-SBP) and sepsis.</p>Methods<p>This retrospective study included patients with cirrhosis who were hospitalized at the First People’s Hospital of Changde City, China, between May 2021 and June 2025. The exposure variable was the first serum magnesium measurement obtained within 48 hours of admission. The primary outcome was HA-SBP, and the secondary outcome was sepsis. Multivariable regression and restricted cubic spline (RCS) analyses were used to assess the associations.</p>Results<p>A total of 1110 patients with cirrhosis were included. The incidences of HA-SBP and sepsis were 12.25% and 6.06%, respectively. Multivariable regression analysis showed that per 1-SD increase in serum magnesium, the risks of HA-SBP and sepsis decreased by 20.8% (odds ratio [OR] = 0.792, 95% confidence interval [CI]: 0.642–0.970, P = 0.026) and 35.5% (OR = 0.645, 95% CI: 0.464–0.883, P = 0.008), respectively. Compared with normomagnesemia, hypomagnesemia was associated with increased risks of HA-SBP (OR = 1.520, 95% CI: 1.009–2.286, P = 0.044) and sepsis (OR = 2.213, 95% CI: 1.189–4.177, P = 0.013). Sensitivity analyses yielded consistent results. RCS analysis showed a linear inverse association between serum magnesium levels and the risks of HA-SBP and sepsis (both P for nonlinearity > 0.05). In addition, the areas under the receiver operating characteristic curves for serum magnesium in predicting HA-SBP and sepsis were 0.635 (95% CI: 0.583–0.686) and 0.688 (95% CI: 0.617–0.758), respectively.</p>Conclusions<p>Hypomagnesemia was associated with increased risks of HA-SBP and sepsis in patients with cirrhosis, and these findings should be further validated in prospective studies.</p> 2026-09-15T04:27:53Z Dataset Dataset 10.3389/fimmu.2026.1857975.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Association_of_serum_magnesium_levels_with_the_risk_of_spontaneous_bacterial_peritonitis_and_sepsis_in_hospitalized_patients_with_cirrhosis_a_retrospective_cohort_study_docx/33770827 CC BY 4.0