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Additional file 1 of Metabolic rewiring at the pyruvate node contributes to severe pneumonia and attenuation of T cell responses in serotype 3 Streptococcus pneumoniae infection Kenichi Takeshita (21697294) Ana G. Jop Vidal (21523022) Jorge E. Vidal (13192944) Biochemistry Space Science Medicine Microbiology Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified Cancer Infectious Diseases themis ), consistent streptococcus pneumoniae remains novel hallmark mechanism g ., rag1 bronchial epithelial membranes pyruvate node contributes like structure formation dependent reduced expression dependent pathway contributes sensitive growth defect invasive pneumococcal disease indicating metabolic burden pyruvate metabolic node like structures represent forming prominent bacterium like structures pyruvate flux dependent fitness vitro growth pneumococcal pathogenesis metabolic rewiring metabolic adaptation structures appeared δspxbδlcto mutants unique oxygen uncontrolled dissemination strain wu2 strain exhibited severe pneumonia quantitative rt poorly defined perivascular inflammation pcr ). part due major cause lcto pathways largely absent isogenic δspxb investigated oxygen colonization efficiency cell responses cell activation bacterial translocation bacterial burdens amplified inflammation Supplementary Material 1: Table S1. Dysregulated genes from bulk RNA-seq analysis of mouse lung tissue (log2FoldChange ≥ 1, and padj <0.05). 2026-06-22T05:00:00Z Dataset Dataset 10.6084/m9.figshare.33770432.v1 https://figshare.com/articles/dataset/Additional_file_1_of_Metabolic_rewiring_at_the_pyruvate_node_contributes_to_severe_pneumonia_and_attenuation_of_T_cell_responses_in_serotype_3_Streptococcus_pneumoniae_infection/33770432 CC BY