2026-10-12T14:20:41Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33770046 2026-09-15T03:09:02Z category_4 category_7 category_12 category_15 category_272 category_873 category_811 category_61 category_64 category_69 category_128 category_135 portal_63 item_type_3 month_year_09_2026

Nontargeted Analysis of the Chemical Exposome in Preterm Birth: A Pilot Study of Placenta and Maternal Serum Xiaowen Ji (4235518) Mathusa Lakuleswaran (20159142) Wenjie Lyu (24252931) Marina Sirota (87296) Arthur David (1497043) Xianchuan Xie (1952848) Julian Edwards (23005831) Miaomiao Wang (2173534) June-Soo Park (1414483) Dimitri Abrahamsson (11300063) Biochemistry Medicine Cell Biology Neuroscience Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Developmental Biology Cancer Inorganic Chemistry Hematology Computational Biology resolution mass spectrometry new york city metabolic disruptions associated e ., dodecyltrimethylammonium confirmed 29 chemicals 83 pregnant women level 3 ). human blood samples untargeted chemical profiling orbitrap hrms ). paired maternal serum level 2 ), 05 ). orbitrap high chemical exposures chemical exposome using ultrahigh triphenylphosphine oxide targeted analysis study appear silico </ previously detected preterm birth pilot study phospholipid pathways p </ oxidative stress nontargeted analysis neonatal morbidity lipid metabolism leading cause including 30 identified 119 dimethyldecylamine oxide data suggest arachidonic acid Preterm birth is a leading cause of neonatal morbidity and mortality, yet the role of chemical exposures in its etiology remains poorly understood. We hypothesized that untargeted chemical profiling of paired maternal serum and placenta would reveal distinct exposure signatures and metabolic disruptions associated with preterm birth. We analyzed paired maternal serum and placenta samples from 83 pregnant women in New York City, USA, including 30 who delivered preterm (<37 weeks), by non-targeted analysis (NTA) using ultrahigh-performance liquid chromatography coupled to Orbitrap high-resolution mass spectrometry (UHPLC-Orbitrap HRMS). We confirmed 29 chemicals (Level 1), 28 of them exogenous, tentatively identified 1012 peak features (Level 2), and annotated 1180 peak features via <i>in silico</i> simulation (Level 3). Five Level 1 confirmed exogenous chemicals (i.e., dodecyltrimethylammonium, N,N-dimethyldecylamine oxide, rimsulfuron, triphenylphosphine oxide, and 2,6-dichlorobenzamide) and 208 tentatively identified Level 2 chemicals detected in this study appear not to have been previously detected in human blood samples. We identified 119 and 170 significantly differentially enriched features in serum and placenta, respectively (BH-corrected <i>p</i> < 0.05). Serum samples showed changes in glutathione, tryptophan, pyruvate, arachidonic acid, and phospholipid pathways in preterm birth. Our data suggest that chemical exposures might collectively amplify metabolic vulnerabilities in oxidative stress, lipid metabolism, and amino acid catabolism relevant to preterm birth. 2026-09-14T00:00:00Z Dataset Dataset 10.1021/envhealth.6c00264.s002 https://figshare.com/articles/dataset/Nontargeted_Analysis_of_the_Chemical_Exposome_in_Preterm_Birth_A_Pilot_Study_of_Placenta_and_Maternal_Serum/33770046 CC BY-NC 4.0