2026-10-14T03:25:41Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33769990 2026-09-15T03:17:55Z category_24862 item_type_3 month_year_09_2026

Super tRNA-Tumor suppressor gene-Manual Bangyan Kong (24910702) Pharmaceutical sciences TP53 gene mutations APC gene mutations RB1 mutation PTEN mutations <p dir="ltr">Super tRNA-tumor suppressor gene-Manual. Based on the COSMIC database, we compiled all reported nonsense mutation types for the four tumour suppressor genes TP53, RB1, PTEN, and APC, and established corresponding super tRNA-manuals for each of these genes. We predicted the missense mutation effects for the saturated mutagenesis of each nonsense mutation site and generated a heatmap corresponding to each nonsense mutation. The heat map corresponds to the predictive impact of each variant ranging from -1 (Red, Pathogenic) to 1 (Blue, Benign), with the lowest score being the most deleterious. Scores were obtained from nine algorithms, including PredictSNP, MAPP, PhD-SNP, PolyPhen-1, PolyPhen-2, SIFT, SNAP, PANTHER and Alphamissense. Based on this analysis, we provide tailored sup-tRNA selection recommendations for therapeutic targeting of each nonsense mutation. </p> 2026-09-15T03:17:55Z Dataset Dataset 10.6084/m9.figshare.33769990.v1 https://figshare.com/articles/dataset/Super_tRNA-Tumor_suppressor_gene-Manual/33769990 CC BY 4.0