2026-10-07T23:34:42Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33768535 2026-09-14T23:42:28Z portal_1197 item_type_3 month_year_09_2026

Data for Photoactivatable cell-selective dinuclear trans-diazidoplatinum(IV) anticancer prodrugs Huayun Shi (3928973) Isolda Romero-Canelón (8010029) Monika Hreusova (5900453) Olga Novakova (11631) V. Venkatesh (1744150) Abraha Habtemariam (1338636) Guy J. Clarkson (1301127) Ji-Inn Song (4686754) Viktor Brabec (11634) Peter J. Sadler (1297341) Antineoplastic agents -- Development Platinum compounds -- Therapeutic use Cisplatin Azides Photochemistry Migrated from ePrints Novel all-trans dinuclear PtIV complexes bridged by a dicarboxylate linker, highly stable in the dark, generate azidyl and hydroxyl radicals upon irradiation with blue light. They are photocytotoxic to human cancer cells, whereas cisplatin was inactive under these conditions and more photoactive toward cisplatin-resistant ovarian cancer cells compared to wild-type cells. Remarkably, the dinuclear complexes were relatively nontoxic toward normal human cells. Cell cycle and DNA binding experiments suggested that DNA is a target. 2018-01-01T00:00:00Z Dataset Dataset 10.82444/warw.33768535.v1 https://figshare.com/articles/dataset/Data_for_Photoactivatable_cell-selective_dinuclear_trans-diazidoplatinum_IV_anticancer_prodrugs/33768535 CC BY 3.0