2026-10-12T21:34:47Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33736081 2026-09-14T12:48:33Z category_24193 item_type_3 month_year_09_2026

<b>An Integrated Bioinformatics-Experimental Framework Reveals the Mitochondrial-Ferroptosis Axis in Sarcopenia Pathogenesis</b> Aisha Jiang wumaer (24880972) Genomics and transcriptomics Sarcopenia Ferroptosis Mitochondria Biomarkers Machine learning Single-cell analysis <p dir="ltr">Bulk transcriptomic profiles were combined with single-cell RNA sequencing data. Differentially expressed genes were overlapped with MitoCarta3.0 mitochondrial-related genes and ferroptosis-related genes. Random forest, support vector machine, and LASSO models were applied for feature selection and cross-dataset validation. Functional enrichment, immune infiltration, regulatory network construction, and single-cell trajectory analyses were conducted. C2C12 myoblast assays were used to validate mitochondrial injury associated with ferroptosis.</p> 2026-09-14T12:48:33Z Dataset Dataset 10.6084/m9.figshare.33736081.v1 https://figshare.com/articles/dataset/_b_An_Integrated_Bioinformatics-Experimental_Framework_Reveals_the_Mitochondrial-Ferroptosis_Axis_in_Sarcopenia_Pathogenesis_b_/33736081 CC BY 4.0 Open Access after 2028-09-14