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Hydroboration
of Alkynes Catalyzed by Fe(II) PCP Pincer
Complexes
Matthias Käfer (24668527)
Luis F. Veiros (1296141)
Karl Kirchner (1292109)
Biophysics
Biochemistry
Cell Biology
Biotechnology
Evolutionary Biology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Sociology
Cancer
pr )( κ
pr )( ch
pcp pincer complexes
equally active pre
stable alkyl fe
2 </ sub
active pre
syn </
selectively borylated
reaction requires
provided based
mechanistic insights
internal alkynes
experimental data
dft calculations
catalytic conditions
catalysts afford
cases highly
broad variety
alkynes catalyzed
aliphatic alkynes
>- selective
A stereo- and regioselective Fe(II)-catalyzed hydroboration
of
both terminal and internal alkynes with pinacolborane (HBpin) is described.
The hydroboration reaction is in all cases highly <i>syn</i>-selective. The reaction requires no additives and proceeds with
a catalyst loading of 1–2 mol % at 45–55 °C. An
active pre-catalyst is the bench-stable alkyl Fe(II) complex [Fe(PCP<sup>CH2</sup>-<i>i</i>Pr)(CH<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub>)(CO)<sub>2</sub>]. This complex reacts with an excess of
HBpin to form the Fe(II) pinacolborane complex [Fe(PCP<sup>CH2</sup>-<i>i</i>Pr)(κ<sup>2</sup>-H<sub>2</sub>BPin)(CO)],
which is an equally active pre-catalyst but more difficult to handle,
as it decomposes in the absence of substrates. Both pre-catalysts
afford the highly reactive hydride catalyst [Fe(PCP<sup>CH2</sup>-<i>i</i>Pr)(H)(CO)] under catalytic conditions. A broad variety
of aromatic and aliphatic alkynes were efficiently and selectively
borylated. Mechanistic insights are provided based on experimental
data and DFT calculations.
2026-09-14T00:00:00Z
Dataset
Dataset
10.1021/acs.organomet.6c00268.s001
https://figshare.com/articles/dataset/Hydroboration_of_Alkynes_Catalyzed_by_Fe_II_PCP_Pincer_Complexes/33731939
CC BY-NC 4.0