2026-10-13T07:00:49Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33724679 2026-09-14T09:05:48Z category_4 category_21 category_873 category_45 category_46 category_931 portal_63 item_type_3 month_year_09_2026

Camphor-Based NHC Ruthenium Catalysts in AROCM: Influence of Catalyst Structure on Enantio- and E/Z Selectivity Daniel Kamzol (21787213) René Wilhelm (2428207) Biochemistry Biotechnology Chemical Sciences not elsewhere classified Sociology Immunology Information Systems not elsewhere classified provide valuable insights modified catalysts displayed distinct trends observed ligand architecture enabled achieving simultaneous control tuning catalyst performance z </ italic ligand design catalytic performance z </ catalyst structure catalyst reactivity ee </ systematic modification substituent size significant enhancement opening cross new class modern catalysis key challenge findings highlight electronic effects e -</ detailed investigation critical role complexes favored catalytic activity asymmetric ring >, albeit The development of stereoselective olefin metathesis remains a key challenge in modern catalysis, particularly in achieving simultaneous control over the enantioselectivity and <i>Z</i>-selectivity. In this study, a new class of camphor-derived chiral NHC ruthenium complexes was designed, synthesized, and evaluated in asymmetric ring-opening cross-metathesis. Systematic modification of the ligand architecture enabled a detailed investigation of steric and electronic effects on catalytic performance. The prepared catalyst series exhibited high activity in asymmetric ring-opening cross-metathesis (AROCM) reactions, with distinct trends observed between substituent size, catalyst reactivity, and stereoselectivity. While most complexes favored the formation of <i>E-</i>isomers, selected systems provided moderate to high enantioselectivity for <i>Z</i> products. Catechodithiolate-modified catalysts displayed a significant enhancement in <i>Z</i>-selectivity and enantioselectivity, achieving up to 99% <i>ee</i>, albeit at the expense of the catalytic activity. These findings highlight the critical role of ligand design in tuning catalyst performance and provide valuable insights into the structure–selectivity relationships governing asymmetric <i>Z</i>-selective olefin metathesis. 2026-09-14T00:00:00Z Dataset Dataset 10.1021/acs.organomet.6c00151.s002 https://figshare.com/articles/dataset/Camphor-Based_NHC_Ruthenium_Catalysts_in_AROCM_Influence_of_Catalyst_Structure_on_Enantio-_and_E_Z_Selectivity/33724679 CC BY-NC 4.0