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oai:figshare.com:article/33718969 2026-09-14T05:40:27Z category_393 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Controlled low central venous pressure after cardiopulmonary bypass reduces acute kidney injury following cardiac surgery: a randomized controlled trial.docx Lihai Chen (3234483) Lanxin Hu (12036968) Yi He (408132) Siyu Kong (15282583) Jiacong Liu (13154064) Ke Ding (309244) Chen Zhang (66790) Duanqi Zhu (24720889) Yi Cheng (317041) Hongwei Shi (2880680) Jifang Zhou (7296194) Yali Ge (417371) Foetal Development and Medicine acute kidney injury cardiac surgery cardiopulmonary bypass central venous pressure controlled low central venous pressure venous congestion Background<p>Postoperative acute kidney injury (AKI) is a serious complication of cardiac surgery. This study aimed to determine whether targeting central venous pressure (CVP) readings of ≤10 mmHg using vasoactive drugs and reversing the Trendelenburg position was associated with a lower incidence of AKI than usual care in patients undergoing cardiac surgery requiring cardiopulmonary bypass (CPB).</p>Methods<p>We conducted a randomized controlled trial. Patients were randomized in a 1:1 ratio to receive controlled low central venous pressure (CLCVP) or usual care. Patients in the CLCVP group received nitroglycerin and were placed in the reverse Trendelenburg position from 20 min after CPB until the end of surgery. The primary outcome was incidence of 7-day postoperative AKI defined by KDIGO criteria.</p>Results<p>The trial included 505 subjects in the final analysis. There were fewer patients with postoperative AKI in the CLCVP group [114 (44.9%)] compared with the control group [150 (59. 8%)] [Absolute risk reduction (ARR): −14.9%; 95% confidence interval [CI]: (−23. 5%, −6. 3%); P = 0. 001]. Eight (3.1%) participants in the CLCVP group and 14 (5.6%) participants in the control group developed AKI of Stage 2 and above [ARR: −2. 4%; 95% CI: (−6. 0, 1. 1%); P = 0. 263]. This reduction was primarily driven by a lower incidence of Stage 1 AKI, whereas the incidence of Stage 2 or higher AKI did not differ significantly between groups. Median time-weighted CVP was lower in the CLCVP group (6.7 mm Hg vs. 8.1 mm Hg, P < 0. 001).</p>Conclusion<p>This randomized clinical trial demonstrated that cardiac surgery patients with CLCVP exhibited lower CVP and fewer postoperative kidney injuries compared to those receiving usual care.</p>Clinical Trial Registration<p>https://clinicaltrials.gov/study/NCT05855954, identifier NCT05855954.</p> 2026-09-14T05:40:27Z Dataset Dataset 10.3389/fmed.2026.1846773.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Controlled_low_central_venous_pressure_after_cardiopulmonary_bypass_reduces_acute_kidney_injury_following_cardiac_surgery_a_randomized_controlled_trial_docx/33718969 CC BY 4.0