2026-10-13T04:52:48Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33718900 2026-09-14T05:38:16Z category_393 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Effects of long-term inhaled corticosteroids on growth velocity and adult height in children with asthma: a systematic review and meta-analysis.docx Jinguang Zhao (24868309) Aiai Dong (18422306) Yibu Kong (11801105) Tianlong Xie (19817751) Xinyan Yu (158875) Baoxin Li (589831) Tianbao Tan (5817002) Jiqiang Mi (24868312) Yinan Guo (7886960) Foetal Development and Medicine adult height asthma children growth velocity inhaled corticosteroids meta-analysis systematic review Background<p>Inhaled corticosteroids (ICS) are the cornerstone of long-term controller therapy for childhood asthma, but their effects on growth remain controversial.</p>Objective<p>To evaluate the effects of long-term maintenance ICS therapy on linear growth velocity and adult or near-adult height in children with asthma.</p>Methods<p>We conducted a systematic review and meta-analysis in accordance with PRISMA 2020. The review was registered in PROSPERO on 27 March 2026 (CRD420261351837), after completion of the database searches on 26 March 2026 but before final study selection, data extraction, risk-of-bias assessment, and quantitative synthesis. PubMed/MEDLINE, Embase, CENTRAL, CNKI, WanFang, and SinoMed were searched from inception to March 26, 2026, with supplementary searches of ClinicalTrials.gov, WHO ICTRP, and reference lists. Eligible studies included children and adolescents with asthma receiving ICS for at least 6 months. Random-effects models were used to pool mean differences (MDs) with 95% confidence intervals (CIs).</p>Results<p>Thirteen studies were included, and six study reports contributed to at least one quantitative analysis. In the primary random-effects meta-analysis, ICS treatment was associated with a non-significant reduction in linear growth velocity compared with controls (MD, −0.38 cm/year; 95% CI, −0.84 to 0.07; I² = 64%). After excluding studies judged to be at high risk of bias, the pooled estimate became statistically significant (MD, −0.59 cm/year; 95% CI, −1.10 to −0.07), suggesting a possible small reduction in linear growth velocity rather than definitive evidence of an effect. A reduction was observed in school-age children (MD, −0.50 cm/year; 95% CI, −0.96 to −0.04), although age-specific differences remained uncertain. Limited long-term evidence suggested a small reduction in adult height (MD, −1.20 cm; 95% CI, −1.90 to −0.50).</p>Conclusion<p>In the primary analysis, long-term maintenance ICS therapy did not demonstrate a statistically significant reduction in linear growth velocity in children with asthma. However, sensitivity analysis excluding studies at high risk of bias suggested a possible small reduction. Evidence regarding adult height was limited and derived predominantly from one long-term follow-up study. These findings should therefore be interpreted cautiously and balanced against the established benefits of ICS for asthma control.</p> 2026-09-14T05:38:16Z Dataset Dataset 10.3389/fmed.2026.1937498.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Effects_of_long-term_inhaled_corticosteroids_on_growth_velocity_and_adult_height_in_children_with_asthma_a_systematic_review_and_meta-analysis_docx/33718900 CC BY 4.0