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oai:figshare.com:article/33717805 2026-09-14T04:31:35Z category_140 portal_316 item_type_3 month_year_09_2026

Table 1_Prognostic value of the atherogenic index of plasma combined with lactate-to-albumin ratio for in-hospital mortality in patients with acute myocardial infarction complicated by cardiogenic shock.docx Yinsheng Jin (24867739) Kai Yang (73590) Lingling Yao (4577968) Cardiology acute myocardial infarction atherogenic index of plasma cardiogenic shock lactate-to-albumin ratio nomogram prognosis Background<p>Acute myocardial infarction complicated by cardiogenic shock (AMICS) carries high in-hospital mortality. We evaluated the combined prognostic value of the Atherogenic Index of Plasma (AIP), reflecting lipid metabolism, and the Lactate-to-Albumin Ratio (LAR), reflecting tissue hypoperfusion and inflammation, in AMICS.</p>Methods<p>This retrospective cohort included 207 consecutive patients with AMICS between January 2023 and January 2025, classified as survivors (n = 174) or non-survivors (n = 33). Admission clinical, laboratory, echocardiographic, and treatment variables were collected. Least Absolute Shrinkage and Selection Operator (LASSO) regression selected candidate predictors; multivariable logistic regression identified independent predictors and generated a nomogram. Performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration metrics, bootstrap internal validation, and decision curve analysis.</p>Results<p>Non-survivors had higher AIP (0.33 ± 0.23 vs. 0.06 ± 0.30) and LAR than survivors (P < 0.05). LASSO identified six candidate predictors. Mechanical ventilation (OR = 10.10, 95% CI: 3.09–33.09, P < 0.001), LVEF <40% (OR = 3.49, 95% CI: 1.23–9.90, P = 0.019), AIP (OR = 4.30 per SD increase, P < 0.001), and LAR (OR = 1.88 per SD increase, P = 0.005) were independently associated with in-hospital mortality. The combined model showed good-to-excellent internal discrimination (AUC = 0.909, bootstrap 95% CI: 0.853–0.957), exceeding AIP (AUC = 0.777) or LAR (AUC = 0.735) alone. Calibration was acceptable (Hosmer–Lemeshow P = 0.853; Brier score = 0.077, bootstrap 95% CI: 0.052–0.103). The model underwent internal validation only and should be considered hypothesis-generating pending external validation.</p>Conclusion<p>AIP and LAR were independently associated with in-hospital mortality and may reflect complementary lipid-metabolic and hypoperfusion-inflammatory pathways. The nomogram combines these biomarkers with hemodynamic and respiratory severity parameters and may support early risk stratification, but requires external multicenter validation before routine clinical use.</p> 2026-09-14T04:31:35Z Dataset Dataset 10.3389/fcvm.2026.1816471.s001 https://figshare.com/articles/dataset/Table_1_Prognostic_value_of_the_atherogenic_index_of_plasma_combined_with_lactate-to-albumin_ratio_for_in-hospital_mortality_in_patients_with_acute_myocardial_infarction_complicated_by_cardiogenic_shock_docx/33717805 CC BY 4.0