2026-10-07T20:05:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33716545 2026-09-13T21:04:58Z category_24196 category_24175 category_24733 item_type_3 month_year_09_2026

Chronos-PD: Sensitivity Analysis Outputs Nathan Watson-Haigh (24550035) Benoit Lehallier (5310353) Proteomics and metabolomics Systems biology Central nervous system Chronos Chronos-PD Proteomics Biomarkers Longitudinal proteomics Sensitivity analysis <p dir="ltr"><b>Sensitivity Analysis Summary Results for the Chronos-PD Revision</b></p><p dir="ltr">This archive contains summary-level outputs from sensitivity analyses performed during the revision of the Chronos-PD manuscript. The analyses were conducted to evaluate the robustness of the primary findings across alternative sample subsets and analytical frameworks.</p><p dir="ltr">The archive includes results from:</p><ul><li>Longitudinal mixed-effects models (LMM)</li><li>Joint models (JM)</li><li>Protein-ratio analyses</li></ul><p dir="ltr">Results are organized according to two hierarchical dimensions:</p><p dir="ltr"><b>Population subset</b></p><ul><li><code>all</code>: all available samples</li><li><code>pre</code>: samples collected before Parkinson's disease diagnosis</li><li><code>post</code>: samples collected after Parkinson's disease diagnosis</li></ul><p dir="ltr"><b>Feature set</b></p><ul><li><code>all</code>: all evaluated proteins or protein ratios</li><li><code>sig</code>: proteins or protein ratios that were statistically significant in the primary Chronos-PD analysis</li></ul><p dir="ltr">The archive contains summary tables, correlation analyses, protein-count summaries, and heatmap visualizations that facilitate comparison between sensitivity analyses and the primary manuscript results.</p><p dir="ltr">Files are provided in tab-separated value (TSV) format and PDF format.</p><p dir="ltr">This resource is intended to support transparency, reproducibility, and evaluation of the robustness of the Chronos-PD findings.</p><p dir="ltr">A detailed README describing the directory structure, naming conventions, output types, and interpretation of results is included in the archive.</p><p dir="ltr"><b>Important note:</b> The <code>sig</code> designation identifies features that were statistically significant in the primary Chronos-PD analysis. It does not imply statistical significance in every sensitivity analysis.</p><p dir="ltr">This archive contains summary-level results only. Participant-level data are not included and remain available through governed-access research environments subject to applicable privacy protections and data-use agreements.</p> 2026-09-13T21:04:58Z Dataset Dataset 10.6084/m9.figshare.33716545.v1 https://figshare.com/articles/dataset/Chronos-PD_Sensitivity_Analysis_Outputs/33716545 CC BY 4.0