2026-10-13T09:07:57Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33713959 2026-09-13T17:07:43Z portal_1197 item_type_3 month_year_09_2026

Data for Hydrogen Bonding in Alzheimer’s Amyloid-β Fibrils Probed by15N{17O} REAPDOR Solid-State NMR Spectroscopy Juan Wei (498096) Oleg N. Antzutkin (1296813) Andrei V. Filippov (1753414) Dinu Iuga (1345257) Pui Yiu Lam (2033866) Mark P. Barrow (1756480) Ray Dupree (1356219) Steven P. Brown (1296819) Peter B. O'Connor (2535301) Hydrogen bonding Amyloid Alzheimer's disease -- Physiological aspects Migrated from ePrints An exclusive label: 15N{17O} REAPDOR NMR was used to validate intermolecular C17O⋅⋅⋅H15N hydrogen bonding in Ac-Aβ(16–22)-NH2 (see scheme) and Aβ(11–25) amyloid fibrils, which are associated with Alzheimer's disease, by selectively labeling them with 17O and 15N. This method was effective for confirming the structure of these fibrils, and could be useful for a number of other biological samples.<br><br>Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State NMR and Ultra-High Resolution FTICR-MS All data are Bruker NMR data sets recorded by Oleg Antzutkin and Dinu Iuga 2016-03-21T00:00:00Z Dataset Dataset 10.82444/warw.33713959.v1 https://figshare.com/articles/dataset/Data_for_Hydrogen_Bonding_in_Alzheimer_s_Amyloid-_Fibrils_Probed_by15N_17O_REAPDOR_Solid-State_NMR_Spectroscopy/33713959 CC BY 4.0