2026-10-07T16:18:13Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33705421 2026-09-13T15:00:08Z category_24826 item_type_3 month_year_09_2026

Supporting experimental data for therapeutic effects of retinal organoid-derived exosomes on RGC survival in chronic ocular hypertensive rat model Si Hyung Lee (24859213) Vision science Retinal organoid glaucoma exosome retinal ganglion cell <p dir="ltr">These dataset comprises in vivo and in vitro findings evaluating the neuroprotective efficacy of human induced pluripotent stem cell-derived retinal organoid exosomes in a rat model of chronic ocular hypertension. The provided files include rquantitative data from retinal ganglion cell (RGC) survival analyses via Brn3a immunostaining, visual function preservation assessed by photopic negative response (PhNR) measurements, and early-stage (day 3) MAPK pathway protein phosphorylation assays (ERK, JNK, p38). Please note that the exosomal microRNA profiling highlighting MAPK-targeting miRNAs and 1-month post-treatment total RNA sequencing data, which detail the transcriptomic modulation of fatty acid beta-oxidation and immune responses in the COH retina, have been deposited separately in the Gene Expression Omnibus.</p> 2026-09-13T15:00:08Z Dataset Dataset 10.6084/m9.figshare.33705421.v1 https://figshare.com/articles/dataset/Supporting_experimental_data_for_therapeutic_effects_of_retinal_organoid-derived_exosomes_on_RGC_survival_in_chronic_ocular_hypertensive_rat_model/33705421 CC BY 4.0 Open Access after 2028-09-13