2026-10-06T19:23:46Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33435853 2026-09-28T11:40:43Z category_24184 category_24193 category_24202 item_type_3 month_year_09_2026

Supplementary Datasets and Data-Package for <b><i>CRISPR-enhanced assessment of variants of unknown significance nominates oncology therapeutic targets and drug repositioning opportunities</i></b> Savino et Al. 2026 Francesco Iorio (6370019) Bioinformatic methods development Genomics and transcriptomics Statistical and quantitative genetics tested variants decoy set <p dir="ltr">This repository contains supplementary datasets and the data package required to reproduce the analysis, results, and figures presented in Savino et al. (2026).<br><br>The study leverages CRISPR-based functional genomics to systematically evaluate Variants of Unknown Significance (VUS) in oncology, identifying actionable therapeutic targets and highlighting novel opportunities for drug repositioning.<br><br>The complete computational workflow is available at https://github.com/francescojm/CRISPR-VUS.</p><p dir="ltr">The repository contains a Jupyter notebook, accompanying R scripts, configuration files, software-environment information and instructions for reproducing the analyses and figures. The notebook can also be accessed through Google Colab (at https://colab.research.google.com/drive/1PkduxjbHQH4zZxk3g69LWQUGL_jsL-aq?usp=sharing).</p><p><br></p> 2026-09-28T11:40:43Z Dataset Dataset 10.6084/m9.figshare.33435853.v6 https://figshare.com/articles/dataset/Supplementary_Datasets_underlying_analysis_and_results_presented_in_b_CRISPR-enhanced_assessment_of_variants_of_unknown_significance_nominates_oncology_therapeutic_targets_and_drug_repositioning_opportunities_b_Savino_et_Al_2026/33435853 CC BY 4.0