2026-10-14T10:20:45Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33425743 2026-09-23T05:55:10Z category_26275 portal_886 item_type_3 month_year_09_2026

Supporting data for "Agentic and generative AI for biological imaging and strcuture prediction" Chixiang Lu (13819552) Biomedical imaging Microscopy imaging agent <p dir="ltr">Raw data for chapter "micro-copilot" of "Agentic and generative AI for biological imaging and structure prediction". The raw data from the agent measurement for statistical analysis and plotting in all experiments are provided.<br><br>Micro-Copilot implements fluorescence microscopy as a human-in-the-loop acquisition-analysis-reasoning cycle. A reward-based navigation agent controls the microscope hardware, explores the specimen, and centres informative fields. An analysis agent performs real-time cell segmentation, organelle detection, feature extraction, and colocalization analysis. A retrieval-grounded co-scientist integrates population statistics with experimental metadata and literature to propose mechanistic hypotheses. The platform quantified tens of thousands of organelles within hours across five lysosome studies and, through iterative discovery cycles, uncovered a previously unknown mechanism in which the GPX4 inhibitor RSL3 drives lysosomal hyperacidification through autophagy-dependent V-ATPase assembly.<br></p> 2026-09-23T05:55:10Z Dataset Dataset 10.25442/hku.33425743.v1 https://figshare.com/articles/dataset/Supporting_data_for_Agentic_and_generative_AI_for_biological_imaging_and_strcuture_prediction_/33425743 CC BY-NC 4.0 Open Access after 2029-11-30