2026-10-11T21:46:05Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33383890 2026-09-23T01:39:22Z category_24850 portal_886 item_type_3 month_year_09_2026

Supporting data for "Pharmacological effects, bioactive constituents, and mechanistic pathways of Amauroderma rugosum in atopic dermatitis: an in vitro and in vivo investigation" Ho Ting Shiu (12989561) Basic pharmacology Atopic dermatitis Medicinal mushroom anti-inflammatory <p dir="ltr">This research focus on exploring the Pharmacological effects, bioactive constituents, and mechanistic pathways of Amauroderma rugosum (AR) in atopic dermatitis. The water extract of this AR medicinal mushroom was found to exhibited anti-inflammatory and anti-oxidant effect in inflamed keratinocytes, suggesting its potential as the atopic dermatitis treatment. The crude polysaccharide (PS) was found to be the bioactive constituents of this medicinal mushroom. Mice experiment using DNCB-induced atopic dermatitis mice model was used to confirm its treatment effect in atopic dermatitis. Follow-up mechanistic pathways were identified using RNA sequencing, and in invitro experiments in various immune cell model.</p> 2026-09-23T01:39:22Z Dataset Dataset 10.25442/hku.33383890.v1 https://figshare.com/articles/dataset/Supporting_data_for_Pharmacological_effects_bioactive_constituents_and_mechanistic_pathways_of_Amauroderma_rugosum_in_atopic_dermatitis_an_in_vitro_and_in_vivo_investigation_/33383890 CC BY-NC 4.0 Open Access after 2028-08-31