2026-10-07T10:03:24Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33370711 2026-10-02T12:36:40Z category_24310 category_24301 item_type_3 month_year_10_2026

Integrating genome-wide association and Fst-based selection signature analyses pinpoints candidate loci for body weight in Beagle dogs Siyu Liang (24667663) Mingshuo Wang (24667717) Yanbo Yin (24667722) Haolong Wang (24667724) Can Zhang (24667725) Jiale Li (24667727) Mengjiao Hu (24667738) Yue Yin (24667739) Haiping Zhao (24667743) Zhen Liu (24667746) Keyuan Liu (24667749) Weili Sun (24667752) Lisheng Zhou (24667753) Genomics Gene mapping Beagle Dogs Body Weight Fst GWAS <p dir="ltr">This dataset contains genotype and phenotype data from a genome-wide association study (GWAS) and Fst-based selection signature analysis of body weight in 435 Beagle dogs (190 males and 245 females). Whole-genome resequencing was performed on the DNBSEQ-T7 platform at approximately 5× depth, yielding 162,133 SNPs after quality control. The dataset includes PLINK binary genotype files (.bed, .bim, .fam), body weight phenotypes, covariates (principal components and sex), GWAS summary statistics, significant loci identified by GWAS and Fst overlap analysis, and Fst selection signature results between high- and low-weight groups. GWAS identified ten significant loci (FDR q < 0.05) on chromosomes 6, 10, 17, 23, and 26. Overlap with Fst signals revealed six loci under selection: three intronic variants in HMGA2 on chromosome 10 and three intergenic variants between MED13L and SPRING1 on chromosome 26, reported for the first time in Beagle dogs as associated with body size. The reference genome was Dog10K_Boxer_Tasha (GCF_000002285.5) and annotation was performed with SnpEff v5.4c. This dataset supports the findings in the manuscript "Integrating genome-wide association and Fst-based selection signature analyses pinpoints candidate loci for body weight in Beagle dogs" and is provided for replication and further genetic studies.</p> 2026-10-02T12:36:40Z Dataset Dataset 10.6084/m9.figshare.33370711.v1 https://figshare.com/articles/dataset/Integrating_genome-wide_association_and_Fst-based_selection_signature_analyses_pinpoints_candidate_loci_for_body_weight_in_Beagle_dogs/33370711 CC BY 4.0