2026-10-14T10:34:28Z
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2026-09-30T05:02:59Z
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Synthesis, crystal structures and urease inhibition of copper(II), manganese(III) and nickel(II) complexes derived from 2-bromo-<i>N′</i>-(2-hydroxy-4-methoxybenzylidene) benzohydrazide
Zhonglu You (563032)
Jiayan Dai (24666353)
Haodong Zhang (4417534)
Zhengwei Wu (2051824)
Yaoyao Cao (24666356)
Dahua Shi (12386030)
Biophysics
Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer
Computational Biology
Copper complex
manganese complex
nickel complex
hydrazone
urease inhibition
<p>Hydrazones have interesting biological activities. In this work, three new copper(II), manganese(III) and nickel(II) complexes, [Cu<sub>2</sub>(HL)<sub>2</sub>(OH<sub>2</sub>)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·2H<sub>2</sub>O (<b>1</b>), [MnLL′(CH<sub>3</sub>OH)] (<b>2</b>) and [Ni<sub>2</sub>(HL)<sub>2</sub>(OH<sub>2</sub>)<sub>2</sub>(DMF)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (<b>3</b>), where L is the dianionic form of 2-bromo-<i>N</i>′-(2-hydroxy-4-methoxybenzylidene)benzohydrazide (H<sub>2</sub>L), HL is the deprotonated form of H<sub>2</sub>L, and L′ is the deprotonated form of 4-methoxysalicylaldehyde, were prepared and characterized by physico-chemical methods. Molecular structures of the complexes have been determined by single crystal X-ray crystallography. In complexes <b>1</b> and <b>3</b>, the hydrazone ligands coordinated to the metal atoms through phenolate oxygen, imino nitrogen and carbonyl oxygen atoms. In complex <b>2</b>, the hydrazone ligands coordinated to the manganese atom through phenolate oxygen, imino nitrogen and enolate oxygen atoms. The Cu atoms in complex <b>1</b> are in square pyramidal coordination, and the Mn and Ni atoms in complexes <b>2</b> and <b>3</b> are in octahedral coordination. Crystals of the complexes are stabilized by hydrogen bonds. The complexes were tested for their urease inhibitory activities. Complex <b>1</b> has the most activity on <i>Jack bean</i> urease (IC<sub>50</sub> = 1.4 ± 0.2 μmol L<sup>−1</sup>).</p>
2026-09-30T05:02:59Z
Text
Journal contribution
10.6084/m9.figshare.33366080.v2
https://figshare.com/articles/journal_contribution/Synthesis_crystal_structures_and_urease_inhibition_of_copper_II_manganese_III_and_nickel_II_complexes_derived_from_2-bromo-_i_N_i_-_2-hydroxy-4-methoxybenzylidene_benzohydrazide/33366080
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