2026-10-13T23:33:30Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33365970 2026-09-23T01:22:55Z category_24298 portal_886 item_type_3 month_year_09_2026

Supporting data for "Genome-wide CRISPR/Cas9 library screening identified CDK10 as a potential target of IDH1 inhibitor resistance in mutated IDH1-iCCA" Ho Ying Lau (19329079) Gene expression (incl. microarray and other genome-wide approaches) CDK10 intrahepatic cholangiocarcinomas idh1 inhibitor CRISPR <p dir="ltr">Genome-wide CRISPR-Cas9 knockout library screening in RBE cells (IDH1-R132S) demonstrated that CDK10 may potentially be responsible for AG-120 resistance in mIDH1 iCCA. Functional assays showed that knockdown of CDK10 worked synergistically with AG-120 to inhibit proliferation and induce apoptosis in mIDH1 iCCA cells.</p> 2026-09-23T01:22:55Z Dataset Dataset 10.25442/hku.33365970.v1 https://figshare.com/articles/dataset/Supporting_data_for_Genome-wide_CRISPR_Cas9_library_screening_identified_CDK10_as_a_potential_target_of_IDH1_inhibitor_resistance_in_mutated_IDH1-iCCA_/33365970 CC BY-NC 4.0