2026-10-07T07:29:13Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33346545 2026-09-22T09:21:02Z category_24631 category_24778 category_24787 category_24799 portal_886 item_type_3 month_year_09_2026

<b>Supporting Data for Single and Combinational Immunotherapies to Overcome Isocitrate Dehydrogenase 1 Mutant Intrahepatic Cholangiocarcinoma</b> Xinqi Liu (13008900) Carmen Chak Lui Wong (9052118) Tumour immunology Cancer cell biology Cancer therapy (excl. chemotherapy and radiation therapy) Molecular targets Liver Cancer Cholangiocarcinoma Immunotherapy Targeted Therapy IDH1 Mutation <p dir="ltr">This dataset accompanies a study characterising the immune microenvironment of IDH1-mutant intrahepatic cholangiocarcinoma (iCCA). By investigating the impact of the oncometabolite R-2HG on primary murine cells, novel immunotherapeutic strategies for IDH1-mutant iCCA were identified. The repository contains quantitative IDH1 expression data from engineered murine iCCA cell lines, along with proliferation, apoptosis, Treg proportion, and transcriptomic sequencing data from T cells co-cultured with IDH1-mutant cells or treated with R-2HG. Additionally, data regarding the antigen presentation functionality of bone marrow-derived dendritic cells under R-2HG treatment, as well as tumour burden evaluations following STING agonist therapy, are included.</p> 2026-09-22T09:21:02Z Dataset Dataset 10.25442/hku.33346545.v1 https://figshare.com/articles/dataset/_b_Supporting_Data_for_Single_and_Combinational_Immunotherapies_to_Overcome_Isocitrate_Dehydrogenase_1_Mutant_Intrahepatic_Cholangiocarcinoma_b_/33346545 CC BY-NC 4.0 Embargoed