2026-10-14T05:50:22Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33345753 2026-09-22T09:17:40Z category_24619 portal_886 item_type_3 month_year_09_2026

Supporting data for “A High-Throughput, Low-Cost Platform for Paired BCR Sequencing Reveals Non-Linear Repertoire Remodelling by SARS-CoV-2 Spike Variants” Fanming Jin (11116920) Humoural immunology and immunochemistry B-cell receptor repertoires BCR-Seq spike 1 protein <p dir="ltr">This dataset contains the research data supporting the thesis titled “A High-Throughput, Low-Cost Platform for Paired BCR Sequencing Reveals Non-Linear Repertoire Remodelling by SARS-CoV-2 Spike Variants.” The research project developed a paired BCR sequencing method and applied it to investigate paired B-cell receptor (BCR) repertoire remodelling in response to SARS-CoV-2 spike sequence variation and progressive mutation accumulation. The dataset includes validation data for a newly developed murine paired BCR sequencing method, as well as processed paired BCR repertoire data and corresponding pseudovirus neutralisation assay results from mice immunised with natural SARS-CoV-2 spike variants (WT, D614G, Alpha, Beta and Omicron) and a panel of cumulative Alpha-associated spike mutants. The source data files support the BCR reptoire statistical analyses and visualisations presented in the thesis.</p> 2026-09-22T09:17:40Z Dataset Dataset 10.25442/hku.33345753.v1 https://figshare.com/articles/dataset/Supporting_data_for_A_High-Throughput_Low-Cost_Platform_for_Paired_BCR_Sequencing_Reveals_Non-Linear_Repertoire_Remodelling_by_SARS-CoV-2_Spike_Variants_/33345753 CC BY-NC 4.0 Open Access after 2028-08-26