2026-10-14T06:31:39Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33289605 2026-09-29T17:17:18Z category_24295 portal_349 item_type_1 month_year_09_2026

Supplementary Material for Unger-Wallace et al., 2026 Erica Unger-Wallace (8655003) Viswanathan Satheesh (805902) Dafang Wang (10968782) Andrew J Severin (25132330) Thomas Peterson (4121) Epigenetics (incl. genome methylation and epigenomics) Maize paramutation transposable elements Reversed-Ends Transposition pericarp cytosine methylation sRNA eccDNA <p dir="ltr">Unger-Wallace and co-workers found that alleles of the maize <i>p1 </i>gene for kernel color containing <i>Ac/fAc </i>transposable elements flanking a <i>p1 </i>transcriptional enhancer can induce paramutation, a type of epigenetic silencing. The authors identified DNA circle junctions derived from eccDNA (extrachromosomal circular DNA) produced by aberrant transposition reactions, and they propose that these eccDNA trigger paramutation. On the basis of these findings, the authors propose that <i>Ac/fAc </i>transposition reactions generate eccDNA containing the <i>p1 </i>enhancer, and that transcription of the enhancer-containing eccDNA leads to sRNA accumulation and cytosine methylation of homologous sequences in the <i>p1 </i>gene, triggering <i>p1 </i>paramutation. This novel hypothesis suggests that eccDNA produced by aberrant transposition reactions can have significant impacts on gene expression.</p> 2026-09-29T17:17:18Z Image Figure 10.25386/genetics.33289605.v2 https://figshare.com/articles/figure/Supplementary_Material_for_Unger-Wallace_et_al_2026/33289605 CC BY 4.0