2026-10-14T09:23:21Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33287076 2026-09-21T09:24:49Z category_24553 portal_886 item_type_3 month_year_09_2026

supporting data for "CRISPR-based functional screening identifies <i>ITGAV</i> as a therapeutic target for 5-fluorouracil resistance in colorectal cancer" Jiaxi Li (13134090) Chi Chung Foo (9055793) Lui Ng (9054536) Surgery colorectal cancer chemotherapy ITGAV CRISPR screening chemoresistance-related genes <p dir="ltr">This dataset contains raw and processed experimental data investigating the role of integrin subunit alpha V (ITGAV) in colorectal cancer progression and resistance to 5-fluorouracil (5-FU). The data support a research project that combines CRISPR screening, public gene-expression dataset analysis, clinical sample analysis, quantitative PCR, Western blotting, immunohistochemistry, cell proliferation and colony-formation assays, wound-healing and migration assays, flow-cytometric apoptosis analysis, drug-response and combination-index analyses, and in vivo tumor models, including a patient-derived xenograft model. The study evaluates ITGAV expression and function in colorectal cancer cells and 5-FU-resistant derivatives and investigates whether ITGAV knockdown or pharmacological inhibition with cilengitide can improve cellular responses to 5-FU. The deposited files include spreadsheet data, GraphPad Prism analysis files, flow-cytometry data, statistical reports, an R analysis script, and supporting figure materials. Collectively, these data provide experimental evidence for understanding the association between ITGAV and 5-FU resistance and for evaluating ITGAV as a potential therapeutic target in colorectal cancer.</p> 2026-09-21T09:24:49Z Dataset Dataset 10.25442/hku.33287076.v1 https://figshare.com/articles/dataset/supporting_data_for_CRISPR-based_functional_screening_identifies_i_ITGAV_i_as_a_therapeutic_target_for_5-fluorouracil_resistance_in_colorectal_cancer_/33287076 CC BY-NC 4.0 Open Access after 2029-08-31