2026-10-08T04:11:13Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33285636 2026-09-21T09:24:03Z category_24703 portal_886 item_type_3 month_year_09_2026

Supporting data for "Comparing host response to SARS-CoV and SARS-CoV-2 in normal human bronchial epithelial cells and Syrian hamsters" Chi Cheng Sou (18992261) Medical virology Syrian hamsters NHBE cells host response SARS-CoV SARS-CoV-2 Omicron BA.1 <p dir="ltr">Differentiated normal human bronchial epithelial cells (NHBE) were infected with SARS-CoV (strain: HK39849) or SARS-CoV-2 (strain: hCoV-19/Hong Kong/VM0001061/ 2020) at an MOI of 0.5 or MOCK-infected with PBS, and were collected at 2h, 6h, 24h, 48h, and 72h post-infection (hpi) to determine viral load and host response by TCID50 and bulk RNA sequencing (RNAseq), respectively. Male Syrian hamsters were intranasally inoculated with 10⁵ TCID50 of SARS-CoV, SARS-CoV-2, or PBS. Nasal turbinates and lungs were collected on 1, 2, and 5 days post-inoculation (dpi) to determine viral load and host response. Gene-set enrichment analysis (GSEA) was used to identify pathways of significant biological functions.</p> 2026-09-21T09:24:03Z Dataset Dataset 10.25442/hku.33285636.v1 https://figshare.com/articles/dataset/Supporting_data_for_Comparing_host_response_to_SARS-CoV_and_SARS-CoV-2_in_normal_human_bronchial_epithelial_cells_and_Syrian_hamsters_/33285636 CC BY-NC 4.0 Open Access after 2026-12-01