2026-10-14T14:19:24Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33253551 2026-09-21T01:43:36Z category_24739 portal_886 item_type_3 month_year_09_2026

Supporting data for "TPX2 promotes axonal outgrowth in motor neurons derived from SMA patients" Hiu Tung Shek (19329070) Neurology and neuromuscular diseases iPSC-derived motor neurons TPX2 Spinal muscular atrophy Genetic modifiers <p dir="ltr">This dataset contains supporting data for a thesis investigating the role of TPX2 dysregulation in motor neuron vulnerability in spinal muscular atrophy (SMA). The dataset includes qPCR data from wild-type and SMA patient-derived motor neurons, immunofluorescence images of motor neuron markers, and mouse model data related to TPX2 treatment. The qPCR files contain normalised gene expression data used to assess TPX2 expression and related molecular changes. The immunofluorescence data include original microscopy images in CZI format for markers such as Tuj1, ChAT and DAPI. The mouse data include behavioural measurements and spinal cord immunofluorescence images from an SMA mouse model treated with TPX2-related interventions. Supporting RPG presentation and poster files are also included to provide research context.</p> 2026-09-21T01:43:36Z Dataset Dataset 10.25442/hku.33253551.v1 https://figshare.com/articles/dataset/Supporting_data_for_TPX2_promotes_axonal_outgrowth_in_motor_neurons_derived_from_SMA_patients_/33253551 CC BY-NC 4.0 Open Access after 2031-08-31