2026-10-11T10:34:54Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33135431 2026-09-30T21:47:22Z category_24295 category_24310 item_type_3 month_year_09_2026

Effondrement-Driven Co-Drift: Locus 17B-624(624-bp) Co-Drifts with BRCA1 Promoter Within Same TAD q21.31-Surrogate for E-field Biased BER -1.67 Mb apart Mujeeb Rehman (24445329) Epigenetics (incl. genome methylation and epigenomics) Genomics surrogate biomarker DFT B3LYP/6-31G* electrostatic asymmetry effondrement epigenetic TAD q1.31 Locus 17B-624 <p dir="ltr">Figshare v4 Final 30.09.2026- date for first DFT effondrement calculation in BRCA 1 region. BRCA 1 promoter chr17:43,044,200-43,044,824 0.88 V/nm(22 CpG) co-methylates r=0.96 p<0.001 with distal surrogate Locus 17B–624 ch17:44,800,624 0.80 V/nm (18 CpG, KANSL1-flanking) 1.67 Mb downstream same q21.31 TAD. Mechanism: Watson- Crick electrostatic potential difference DFT B3LYP/6-31G_explains BER bias. DATASET FOR UPCOMING ARTICLE 2- NOT FOR CURRENT NAR-03169-J-2026 ARTICLE 1.</p><p dir="ltr">This Figshare DOI 10.6084/m9.figshare.331335431 is reserved for our NEXT article (Article 2-Effondrement).</p><p dir="ltr">Content: Computational prediction only. BRCA 1 promoter ch17:43,044,200-43,044,824(0.88 V/ nm,22 CpG) and distal locus 17B-624 ch17: 400,800,624 (0.80 V/ nm, 18CpG, KANSL1- flanking ) within same TAD q21.31, 1.67 Mb downstream. Co-drift predicted from strand asymmetric electric fields DFT B3LYP/6-31G*( Watson-Crick electrostatic potential difference). Slope 0.0075 per V/nm, R2=0.81, Pearson r=0.96 for predicted score.</p><p dir="ltr">NOTE TO REVIEWERES: This DOI is for upcomming Article 2-Do not review for NAR-03169-J-2026</p> 2026-09-30T21:47:22Z Dataset Dataset 10.6084/m9.figshare.33135431.v3 https://figshare.com/articles/dataset/Strand_Asymmetric_Electric_Fields_at_CpG_sites_Drive_Biase_Base-Excision_Repair_and_Epigenetic_Drift/33135431 CC BY 4.0