2026-10-06T08:56:09Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33080468 2026-10-05T18:16:49Z category_30334 category_24529 category_30379 item_type_3 month_year_10_2026

Neuroimaging data for "Shared and distinct neural pathways of aversive and appetitive pain-related learning" Jialin Li (24452414) Lea Busch (24519668) Katarina Forkmann (463992) Tamas Spisak (399991) Jaspreet Kaur (130950) Frederik Schlitt-Nguyen (25302217) Katja Wiech (638155) Katharina Schmidt (693864) Ulrike Bingel (242906) Cognitive neuroscience Pain Learning, motivation and emotion capsaicin pain models <p dir="ltr">Individual beta-maps will be made publicly available upon manuscript acceptance.</p><p dir="ltr">In this registered within-subject fMRI study (https://www.drks.de/search/de/trial/DRKS00027448/details), we examined both aversive and appetitive pain learning during acquisition and extinction in 68 healthy individuals. Ratings confirm successful learning, with exploratory analyses suggesting stronger aversive acquisition and incomplete extinction. Both conditions engage the visual cortex during acquisition, with increased connectivity to the right operculum. Aversive acquisition further elicits stronger mediodorsal thalamus activity and heightened connectivity with the locus coeruleus, alongside sustained parahippocampal activation during extinction. Incomplete aversive extinction is linked to ongoing visual cortex activity during pain anticipation. Findings suggest shared neural substrates, but stronger aversive recruitment of rapid encoding and persistent memory systems.<br>Details see https://www.biorxiv.org/content/10.1101/2025.04.02.646781v1.full.pdf.</p> 2026-10-05T18:16:49Z Dataset Dataset 10.6084/m9.figshare.33080468.v2 https://figshare.com/articles/dataset/data_fmri/33080468 CC BY 4.0