2026-10-15T13:41:30Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32995550 2026-07-15T22:46:30Z category_23824 portal_753 item_type_3 month_year_07_2026

An overview of Phytophthora pathogenesis and to summarise progress in arginine-any amino acid-leucine arginine (RxLR) effector Allen Arineitwe (24399503) Lucy Moleleki (9190597) Agricultural molecular engineering of nucleic acids and proteins Phytophthora spp. Arginine-any amino acid-leucine arginine (RxLR) Phytophthora Pathogenesis Phytophthora nicotianae SDG 2 Zero hunger SDG 3 Good health and wellbeing <p dir="ltr">In this dissertation, we report a core RxLR effector secreted by P. nicotianae early during infection and acts as a modulator of host immunity by targeting host proteins at multiple subcellular compartments. We further reveal that the activity of PpRxLR4 is likely to be mediated by crucial IDR-associated AIMs encoded in this effector. In silico mutation analysis of SLiMs predicted damaging implications on structure stability and biological functions. There is still a need for experimental validation of these mutations in planta to further support the effector’s role in mediating protein-protein interactions and effector function. In silico prediction and Y2H screening of potential interactors for PpRxLR4 revealed autophagy-related proteins and growth and development proteins could likely be the partners for this effector.</p> 2026-07-15T22:46:30Z Dataset Dataset 10.25403/UPresearchdata.32995550.v1 https://figshare.com/articles/dataset/An_overview_of_Phytophthora_pathogenesis_and_to_summarise_progress_in_arginine-any_amino_acid-leucine_arginine_RxLR_effector/32995550 CC BY 4.0